|1.||Danysz, Wojciech: 4 articles (10/2009 - 10/2004)|
|2.||Althaus, Michael: 2 articles (01/2011 - 01/2008)|
|3.||Rammes, Gerhard: 2 articles (05/2009 - 02/2006)|
|4.||Danysz, W: 2 articles (02/2001 - 01/2000)|
|5.||Newman, Emily L: 1 article (11/2012)|
|6.||Takahashi, Aki: 1 article (11/2012)|
|7.||Debold, Joseph F: 1 article (11/2012)|
|8.||Chu, Adam: 1 article (11/2012)|
|9.||Bahamón, Brittany: 1 article (11/2012)|
|10.||Miczek, Klaus A: 1 article (11/2012)|
01/01/1999 - "MRZ 2/579 was also effective in protecting hippocampal slices against 7 min. hypoxia/hypoglycaemia-induced reduction of fEPSP amplitude in CA1 with an EC50 of 7.01 +/- 0.24 microM. "
01/01/2000 - "MRZ 2/579 protected cultured cortical neurones against glutamate toxicity with an IC50 of 2.16microM and was also effective in protecting hippocampal slices against hypoxia/hypoglycaemia-induced reduction of fEPSP amplitude in CA1 with an EC50 of 7.01microM. "
01/01/2000 - "MRZ 2/579 has similar potency and bio-availability to memantine in vivo assessed using microdialysis, microiontophoresis and MES-induced seizures. "
01/01/1999 - "Of the compounds tested MRZ 2/579, 2/615, 2/632, 2/633, 2/639 and 2/640 had affinities, kinetics and voltage-dependency most similar to those of memantine and had good therapeutic indices against MES-induced convulsions. "
10/25/2004 - "The effect of neramexane, a low-to-moderate affinity uncompetitive NMDA receptor antagonist, was examined on the development and expression of ethanol dependence (withdrawal-associated audiogenic seizures) and ethanol-induced conditioned place preference. "
02/09/2001 - "The aim of the present study was to evaluate effects of the novel low-affinity, uncompetitive NMDA receptor antagonist, 1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride (MRZ 2/579), on ethanol self-administration and ethanol withdrawal-associated seizures in rats. "
02/09/2001 - "Effects of a novel uncompetitive NMDA receptor antagonist, MRZ 2/579 on ethanol self-administration and ethanol withdrawal seizures in the rat."
|3.||Parkinson Disease (Parkinson's Disease)
01/01/1999 - "In the present study we investigated the potential antiparkinsonian-like activity of compounds acting at the glycine site of the NMDA receptor complex in three animal models of Parkinson's disease and compared them with the new uncompetitive NMDA receptor antagonist MRZ 2/579. "
10/15/2009 - "In conclusion, neramexane and idazoxan counteracted to some extent the development of parkinsonian symptoms and neurochemical alterations in the rotenone model of Parkinson's disease."
05/01/2009 - "Another promising application for neramexane as a neuroprotectant might be chronic neurodegeneration, such as Parkinson's disease, Huntington's disease, vascular dementia, frontal lobe dementia, Down's syndrome and AD. "
08/01/2009 - "Compared with vehicle-treated rats, treatment with neramexane (12.3, 24.6, and 49.2 mg/kg/day) for 2 weeks via an osmotic minipump produced dose-dependent and sustained effects on mechanical hyperalgesia and allodynia. "
01/01/2008 - "Moreover, dynamic mechanical allodynia (pain to light touch) was also significantly attenuated by neramexane (-28% vs. placebo). "
01/01/2008 - "Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia."
01/01/2008 - "The results suggests that in a human surrogate model of neurogenic hyperalgesia a single low-dose of neramexane had a marked analgesic effect in the sensitized and in the non-sensitized state and thus may be a useful drug to treat the enhanced pain sensitivity in neuropathic pain patients. "
09/05/2005 - "Thus, despite expectations based on previous studies, NMDA receptor channel blockers, memantine and neramexane, produce no synergistic interactions with either morphine or clonidine when administered acutely to rats with nerve injury-induced tactile allodynia."
|5.||Alzheimer Disease (Alzheimer's Disease)
10/01/2006 - "Memantine is approved for the treatment of Alzheimer's disease, and neramexane is currently under development for this indication. "
02/01/2006 - "Merz Pharmaceuticals GmbH and Forest Laboratories Inc are developing neramexane, an oral N-methyl-D-aspartate antagonist, as a potential neuroprotectant for various central nervous system disorders, including Alzheimer's disease, and for the potential treatment of drug and alcohol dependence, and pain."
10/01/2004 - "Given the large numbers of subjects who may already have CABG associated cognitive deficits, clinical trials of agents being tested for Alzheimer's disease (eg, donepezil, rivastigmine, memantine, neramexane, ginkgo) may also be informative. "
|1.||Glutamic Acid (Glutamate)
|4.||Morphine (MS Contin)
|5.||Ethanol (Ethyl Alcohol)
|6.||Glycine (Aminoacetic Acid)
|7.||Clonidine (ST 155)
|1.||Self Administration (Administration, Self)