polysaccharide intercellular adhesin

important factor in colonization of medical devices by Staphyococcus epidermidis; consists of two polysaccharides, one of which consists of N-acetylated beta-1-6-linked 2-deoxy-2-aminoglucopyranosyl residues; the other polysaccharide is a phosphorylated, succinylated, and nonacetylated version of the first

Also Known As:

Networked: 38 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pier, Gerald B: 4 articles (04/2020 - 10/2005)
2.	Mack, Dietrich: 4 articles (12/2015 - 03/2005)
3.	Fey, P D: 4 articles (01/2007 - 04/2001)
4.	Rupp, M E: 4 articles (01/2007 - 04/2001)
5.	O'Gara, James P: 3 articles (04/2020 - 05/2007)
6.	Götz, Friedrich: 3 articles (01/2018 - 05/2004)
7.	Fey, Paul D: 3 articles (11/2016 - 02/2007)
8.	Rohde, Holger: 3 articles (12/2015 - 03/2007)
9.	Hirakawa, Hideki: 2 articles (10/2017 - 01/2017)
10.	Hisatsune, Junzo: 2 articles (10/2017 - 01/2017)

Related Diseases

1.	Escherichia coli Infections 05/01/2007 - "Protection against Escherichia coli infection by antibody to the Staphylococcus aureus poly-N-acetylglucosamine surface polysaccharide."
2.	Infections 04/02/2020 - "The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative Acinetobacter baumannii. " 11/01/2016 - "Regulation of icaADBC-encoded polysaccharide intercellular adhesin (PIA)/poly-N-acetylglucosasmine (PNAG) production in staphylococci plays an important role in biofilm-associated medical-device-related infections. " 12/01/2015 - "A major complication of using medical devices is the development of biofilm-associated infection caused by Staphylococcus epidermidis where polysaccharide intercellular adhesin (PIA) is a major mechanism of biofilm accumulation. " 12/01/2015 - "Effects of polysaccharide intercellular adhesin (PIA) in an ex vivo model of whole blood killing and in prosthetic joint infection (PJI): A role for C5a." 04/01/2014 - "Effect of sypQ gene on poly-N-acetylglucosamine biosynthesis in Vibrio parahaemolyticus and its role in infection process."
3.	Autolysis 01/01/2021 - "This is seemingly followed by cooperative repression of autolysis and activation of poly-N-acetylglucosamine (PNAG) production, which may indicate a developmental shift in structuring the biofilm matrix. " 12/01/2021 - "aureus biofilm formation network via down-regulation of the lrg operon, repressor of autolysis, and up-regulation of the ica operon and production of polysaccharide intercellular adhesin (PIA), indicating an increase in eDNA production, and extracellular polysaccharide matrix, respectively. " 01/01/2020 - "In addition, the subinhibitory concentrations of fusidic acid significantly inhibited biofilm formation, autolysis, cell aggregation, and polysaccharide intercellular adhesin (PIA) production of S. " 02/01/2007 - "Vancomycin-intermediate Staphylococcus aureus strains have impaired acetate catabolism: implications for polysaccharide intercellular adhesin synthesis and autolysis." 10/01/2023 - "Although the polysaccharide intercellular adhesin (PIA) production was unaffected, mupirocin significantly facilitated extracellular DNA (eDNA) release by accelerating autolysis, thereby positively triggering cell surface attachment and intercellular agglomeration during biofilm development. "
4.	Catheter-Related Infections 10/01/2006 - "Polysaccharide intercellular adhesin (PIA) is important in the pathogenesis of intravascular catheter-associated infection, and has an essential role in cellular aggregation and biofilm formation. " 04/01/2001 - "Characterization of the importance of Staphylococcus epidermidis autolysin and polysaccharide intercellular adhesin in the pathogenesis of intravascular catheter-associated infection in a rat model." 05/01/1999 - "Characterization of Staphylococcus epidermidis polysaccharide intercellular adhesin/hemagglutinin in the pathogenesis of intravascular catheter-associated infection in a rat model." 05/01/1999 - "A rat central venous catheter (CVC)-associated infection model was used to assess the importance of biofilm production, mediated by polysaccharide intercellular adhesin/hemagglutinin (PIA/HA), in the pathogenesis of intravascular catheter-associated infection. "
5.	Atherosclerotic Plaque (Atheroma) 01/01/2017 - "Staphylococcus aureus TF2758 is a clinical isolate from an atheroma and a super-biofilm-elaborating/polysaccharide intercellular adhesin (PIA)/poly-N-acetylglucosamine (PNAG)-overproducing strain (L. " 10/12/2017 - "Staphylococcus aureus JP080, previously named TF2758, is a clinical isolate from an atheroma and a super biofilm-elaborating strain whose biofilm elaboration is dependent solely on polysaccharide poly-N-acetylglucosamine/polysaccharide intercellular adhesin (PNAG/PIA). "

Related Drugs and Biologics

1.	Polysaccharides (Glycans)
2.	Arginine (L-Arginine)
3.	polysaccharide intercellular adhesin
4.	Proteins (Proteins, Gene)
5.	Polymers
6.	Hemagglutinins (Hemagglutinin)
7.	DNA (Deoxyribonucleic Acid)
8.	Biocompatible Materials (Biomaterials)
9.	Virulence Factors (Pathogenicity Factors)
10.	Mupirocin (Bactroban)

Related Therapies and Procedures

1.	Catheters
2.	Central Venous Catheters
3.	Knee Replacement Arthroplasty (Total Knee Replacement)
4.	Culture Diffusion Chambers