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NSC 314622

structure in first source

Also Known As:

5,6-dihydro-5,11-diketo-2,3-dimethoxy-6-methyl-8,9-methylenedioxy-11H-indeno(1,2-c)isoquinoline; NSC-314622; NSC314622

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        NSC 314622: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - NSC 314622: 2
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - NSC 314622: 2

Experts

1.	Frøhlich, R F: 1 article (03/2001)
2.	Grainge, I: 1 article (03/2001)
3.	Hansen, S G: 1 article (03/2001)
4.	Jayaram, M: 1 article (03/2001)
5.	Knudsen, B R: 1 article (03/2001)
6.	Lisby, M: 1 article (03/2001)
7.	Westergaard, O: 1 article (03/2001)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1998 - "CEM/C2, a CPT-resistant cell line because of a top1 point mutation [Cancer Res 55:1339-1346 (1995)], was cross-resistant to NSC 314622. " 03/09/2001 - "In this study we show that the Int-type recombinase Flp is inhibited by the two structurally unrelated topoisomerase I-directed anti-cancer drugs, camptothecin (CPT) and NSC-314622. "
2.	Breast Neoplasms (Breast Cancer) 07/01/1998 - "DNA damage analyzed in human breast carcinoma MCF7 cells by alkaline elution showed that NSC 314622 induced protein-linked DNA single-strand breaks that reversed more slowly than CPT-induced strand breaks. "

Related Drugs and Biologics

1.	2- cyclohexylidenhydrazo- 4- phenyl- thiazole
2.	Recombinases (Recombinase)
3.	Type I DNA Topoisomerases (Topoisomerase I)
4.	Camptothecin
5.	Proteins (Proteins, Gene)
6.	DNA (Deoxyribonucleic Acid)