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PD 166866

structure in first source

Also Known As:

1-(2-amino-6-(3,5-dimethoxy-phenyl)-pyrido(2,3-d)pyrimidin-7-yl)-3-tert-butyl-urea; PD-166866

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - PD 166866: 2
Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - PD 166866: 2

Related Diseases

1.	Atherosclerotic Plaque (Atheroma) 07/01/1998 - "These results highlight the discovery of PD 166866, a new nanomolar potent and selective small molecule inhibitor of the FGFR-1 tyrosine kinase with potential use as antiproliferative/antiangiogenic agent for such therapeutic targets as tumor growth and neovascularization of atherosclerotic plaques."
2.	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 11/01/2023 - "However, the T-ALL cells were resistant to FGFR1 inhibitors AZD4547 and PD-166866 even though FGFR1 signaling was specifically inhibited in the early stage. "
3.	Neoplasms (Cancer) 07/01/1998 - "These results highlight the discovery of PD 166866, a new nanomolar potent and selective small molecule inhibitor of the FGFR-1 tyrosine kinase with potential use as antiproliferative/antiangiogenic agent for such therapeutic targets as tumor growth and neovascularization of atherosclerotic plaques."

Related Drugs and Biologics

1.	Angiogenesis Inhibitors
2.	Protein-Tyrosine Kinases (Tyrosine Kinase)
3.	AZD4547