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hydrochloride N- diaminomethylene- 2- methyl- 5- methylsulfonyl- 4- pyrrolobenzamide

structure in first source

Also Known As:

N-diaminomethylene-2-methyl-5-methylsulfonyl-4-pyrrolobenzamide, hydrochloride; EMD 85 131; EMD 85131

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Beier, N: 1 article (06/2000)
2.	Gross, G J: 1 article (06/2000)
3.	Gumina, R J: 1 article (06/2000)
4.	Schelling, P: 1 article (06/2000)

Related Diseases

1.

Infarction (Infarctions)

07/01/1998 - "To address this question, the efficacy of several doses of a new selective NHE-1 isoform inhibitor (IC50 for inhibition of 22Na uptake in NHE-1 expressing mouse fibroblast cells = 10.4 +/- 1.0 nM), EMD 85131 (2-methyl-5-methylsulfonyl-1-(1-pyrrollyl)-benzoyl-guanidine), was tested in a canine infarct model in which the left anterior descending coronary artery was occluded for 60 min followed by 3 hr of reperfusion. "
07/01/1998 - "A new sodium/hydrogen exchange inhibitor, EMD 85131, limits infarct size in dogs when administered before or after coronary artery occlusion."
06/01/2000 - "With an in vivo canine infarct model in which the left anterior descending coronary artery was occluded for 60 min and reperfused for 3 h, neither the K(ATP) channel antagonist glibenclamide nor the adenosine-receptor antagonist PD 115199 attenuated NHE-1 inhibitor-mediated reduction in infarct size expressed as a percentage of the area at risk produced by EMD 85131 (Control, 24.2 +/- 3.6%; EMD 85131, 6.4 +/- 2.3%; PD 115199 + EMD 85131, 6.6 +/- 2.4%; glibenclamide + EMD 85131, 3.5 +/- 1.2%). "

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6.	Adenosine Triphosphate (ATP)
7.	N- (2- (dimethylamino)ethyl)- N- methyl- 4- (2,3,6,7- tetrahydro- 2,6- dioxo- 1,3- dipropyl- 1H- purin- 8- yl)benzenesulfonamide