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interleukin-6 receptor alpha

Also Known As:

gp80 IL-6R alpha; interleukin-6R alpha; receptor alpha, interleukin-6

Networked: 15 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Cytokine Receptors: 1620
        Interleukin Receptors: 114
        Interleukin-6 Receptors: 1550
        interleukin-6 receptor alpha: 15

Experts

1.	Blockmans, Daniel: 2 articles (01/2017 - 01/2017)
2.	Brouwer, Elisabeth: 2 articles (01/2017 - 01/2017)
3.	Cid, Maria C: 2 articles (01/2017 - 01/2017)
4.	Collinson, Neil: 2 articles (01/2017 - 01/2017)
5.	Dasgupta, Bhaskar: 2 articles (01/2017 - 01/2017)
6.	Dimonaco, Sophie: 2 articles (01/2017 - 01/2017)
7.	Klearman, Micki: 2 articles (01/2017 - 01/2017)
8.	Rech, Juergen: 2 articles (01/2017 - 01/2017)
9.	Salvarani, Carlo: 2 articles (01/2017 - 01/2017)
10.	Stone, John H: 2 articles (01/2017 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 12/10/2010 - "Knockdown of the interleukin-6 receptor alpha chain of dendritic cell vaccines enhances the therapeutic potential against IL-6 producing tumors."
2.	Rheumatoid Arthritis 12/01/2018 - "This study was conducted to observe patterns of use of the interleukin-6 receptor-alpha inhibitor tocilizumab in routine clinical practice in patients with rheumatoid arthritis (RA). " 11/01/2017 - "To observe patients with rheumatoid arthritis (RA) treated with the interleukin-6 receptor-alpha inhibitor tocilizumab (TCZ) in routine clinical practice. " 02/01/2016 - "Remodeling of plasma lipoproteins in patients with rheumatoid arthritis: Interleukin-6 receptor-alpha inhibition with tocilizumab." 11/01/2020 - "Sarilumab is a human monoclonal antibody blocking the interleukin-6 receptor alpha (IL-6Rɑ) approved for the treatment of moderately to severely active rheumatoid arthritis in adults with inadequate response or intolerance to other disease-modifying antirheumatic drugs. "
3.	Giant Cell Arteritis (Horton Disease) 01/01/2017 - "To report entry criteria and clinical features of patients with newly diagnosed and relapsing giant cell arteritis (GCA) enrolled in a randomized trial of tocilizumab, an interleukin-6 receptor-alpha inhibitor. " 01/01/2017 - "The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid tapering was studied in patients with giant-cell arteritis. "
4.	COVID-19 05/01/2023 - "Immunomodulatory therapy with Tocilizumab (TCZ), a monoclonal antibody against interleukin-6 receptor-alpha, has been endorsed by the World Health Organization and other major regulatory bodies, as part of the standard-of-care therapy for severe or critical COVID-19 cases despite discordant trial outcomes. "
5.	Inflammation (Inflammations) 01/01/2022 - "Interleukin-6 receptor alpha (IL-6Rα) is the receptor of IL-6, a multi-functional cytokine, which plays key roles in liver-regeneration, inflammation and development of hepatocellular carcinoma (HCC). " 01/01/2019 - "The IL-1β stimulation triggered a strong inflammatory response and enhanced the concentrations of matrix metalloproteinase 3 and 13 (MMP-3 and MMP-13), while hyperacute serum treatment reduced inflammation by decreasing the concentrations of IL-1β, tumor necrosis factor alpha (TNF-α), interleukin-6 receptor alpha (IL-6Rα), and by increasing the level of interleukin-1 antagonist (IL-1RA) Cell viability increased by day 5 in the presence of hyperacute serum. " 02/01/2016 - "We hypothesized that RA patients acquire inflammation-induced modifications to the protein cargo of circulating lipoproteins that may be reversed by tocilizumab, an interleukin-6 receptor-alpha inhibitor. " 10/01/2019 - "To better understand the mechanisms associated with Chlamydia-induced genital tract pathogenesis in humans, we used CRISPR genome editing to disrupt Toll-like receptor 3 (TLR3) function in the human oviduct epithelial (hOE) cell line OE-E6/E7 in order to investigate the possible role(s) of TLR3 signaling in the immune response to Chlamydia Disruption of TLR3 function in these cells significantly diminished the Chlamydia-induced synthesis of several inflammation biomarkers, including interferon beta (IFN-β), interleukin-6 (IL-6), interleukin-6 receptor alpha (IL-6Rα), soluble interleukin-6 receptor beta (sIL-6Rβ, or gp130), IL-8, IL-20, IL-26, IL-34, soluble tumor necrosis factor receptor 1 (sTNF-R1), tumor necrosis factor ligand superfamily member 13B (TNFSF13B), matrix metalloproteinase 1 (MMP-1), MMP-2, and MMP-3. "

Related Drugs and Biologics

1.	Interleukin-6 (Interleukin 6)
2.	Vaccines
3.	tocilizumab (atlizumab)
4.	Monoclonal Antibodies
5.	Interleukin-8 (Interleukin 8)
6.	Folate Receptor 1
7.	B-Cell Activating Factor
8.	Toll-Like Receptor 3
9.	Vascular Endothelial Growth Factor D
10.	Vascular Endothelial Growth Factor Receptor-2 (Vascular Endothelial Growth Factor Receptor 2)

Related Therapies and Procedures

1.	Immunomodulation
2.	Therapeutics