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rat NKR-P2 protein

amino acid sequence in first source

Also Known As:

NKR-P2 protein, rat; NKG2D protein, rat; NKR-P2

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Immunologic Receptors: 9
        Natural Killer Cell Receptors: 407
        NK Cell Lectin-Like Receptors
        NK Cell Lectin-Like Receptor Subfamily K: 273
        rat NKR-P2 protein: 4
  - Lectins: 6782
    - C-Type Lectins: 976
      - rat NKR-P2 protein: 4

Experts

1.	Baba, Tomohisa: 2 articles (03/2008 - 03/2006)
2.	Ikeda, Hitoshi: 2 articles (03/2008 - 03/2006)
3.	Ishizu, Akihiro: 2 articles (03/2008 - 03/2006)
4.	Iwasaki, Sari: 2 articles (03/2008 - 03/2006)
5.	Kasahara, Masanori: 2 articles (03/2008 - 03/2006)
6.	Suzuki, Akira: 2 articles (03/2008 - 03/2006)
7.	Tomaru, Utano: 2 articles (03/2008 - 03/2006)
8.	Yoshiki, Takashi: 2 articles (03/2008 - 03/2006)
9.	Khar, Ashok: 2 articles (01/2008 - 04/2004)
10.	Varalakshmi, Chavvakula: 2 articles (01/2008 - 04/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/15/2008 - "The activation of DCs with agonistic anti-NKR-P2 mAb, the binding of soluble NKR-P2 to the AK-5 tumor, and DC maturation with fixed AK-5 cells led us to identify a putative NKR-P2 ligand on the AK-5 cell surface. " 04/01/2004 - "DC activated with anti-NKR-P2 mAb exhibit enhanced apoptotic killing of tumor targets, whereas blocking the interaction between NKR-P2 and its ligand with rNKR-P2 abrogated apoptotic killing, suggesting NKR-P2 to function as an activating molecule on DC. " 01/15/2008 - "In this study we have shown that the AK-5 tumor-derived ischemia-responsive protein-94 (Irp94, a 110 kDa Hsp family member) acts as a functional ligand for NKR-P2 on DCs and enhances Irp94-NKR-P2 interaction-dependent tumor cell apoptosis via NO. Surface expression of Irp94 was also found on tumors of diverse origin in addition to AK-5. " 03/01/2008 - "CD4+CD8+ monocytes/macrophages obtained from preimmunized rats exhibited a Th1-type cytokine/chemokine profile, expressed high levels of Fas ligand, perforin, granzyme B, and NKR-P2 (rat ortholog of human NKG2D), and killed certain tumor cells. "
2.	Ischemia 01/15/2008 - "In this study we have shown that the AK-5 tumor-derived ischemia-responsive protein-94 (Irp94, a 110 kDa Hsp family member) acts as a functional ligand for NKR-P2 on DCs and enhances Irp94-NKR-P2 interaction-dependent tumor cell apoptosis via NO. Surface expression of Irp94 was also found on tumors of diverse origin in addition to AK-5. "
3.	Myocarditis (Carditis) 03/01/2006 - "Consistent with the idea that DP monocytes differentiate into DP macrophages at sites of inflammation, we found infiltration of DP macrophages at the site of myosin-induced myocarditis in wild-type rats; these cells exhibited a T-helper 1 (Th1)-type cytokine/chemokine profile and expressed high levels of Fas ligand, perforin, granzyme B, and NKR-P2 (rat orthologue of human NKG2D). "
4.	Inflammation (Inflammations) 03/01/2006 - "Consistent with the idea that DP monocytes differentiate into DP macrophages at sites of inflammation, we found infiltration of DP macrophages at the site of myosin-induced myocarditis in wild-type rats; these cells exhibited a T-helper 1 (Th1)-type cytokine/chemokine profile and expressed high levels of Fas ligand, perforin, granzyme B, and NKR-P2 (rat orthologue of human NKG2D). "

Related Drugs and Biologics

1.	Ligands
2.	Fas Ligand Protein (Fas Ligand)
3.	Chemokines
4.	Cytokines
5.	perforin-granzyme B
6.	Myosins (Myosin)