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MDP(lysyl)GDP
a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages
Also Known As:
3-O-(N-acetylmuramyl-L-lysyl-D-iso)-2-di-on-glycine
Networked:
1
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Peptides: 82426
Oligopeptides: 519
Dipeptides: 945
MDP(lysyl)GDP: 1
Related Diseases
1.
Allergic Contact Dermatitis
07/01/1998 - "
This study examines whether a water soluble 3-O-[N-acetylmuramyl-L-lysyl-D-iso]-2-di-on-glycine [MDP(Lysyl)GDP], a nontoxic and nonpyrogenic derivative of muramyl dipeptide (MDP), can inhibit the in vitro production of inflammatory mediators by lipopolysaccharide- or interferon-gamma-activated macrophages, and whether such an inhibitory effect can translate into in vivo protection of mice from irritant and allergic contact dermatitis.
"
2.
Otitis
07/01/1998 - "
Likewise, oral treatment with MDP(Lysyl)GDP at days -3, -2, and -1 before elicitation with oxazolone also significantly inhibited ear inflammation.
"
07/01/1998 - "
In mouse models of phorbol ester- and oxazolone-induced ear inflammation, topical application of MDP(Lysyl)GDP significantly suppressed ear swelling in a dose-dependent manner.
"
3.
Inflammation (Inflammations)
07/01/1998 - "
MDP(Lysyl)GDP, a nontoxic muramyl dipeptide derivative, inhibits cytokine production by activated macrophages and protects mice from phorbol ester- and oxazolone-induced inflammation.
"
Related Drugs and Biologics
1.
Lipopolysaccharides
2.
Irritants (Vesicants)
3.
Interferon-gamma (Interferon, gamma)
4.
Glycine (Aminoacetic Acid)
5.
Acetylmuramyl-Alanyl-Isoglutamine
6.
Cytokines
7.
Phorbol Esters
8.
Oxazolone