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tocopheryloxybutyric acid

a nonhydrolysable tocopherol ether analog

Also Known As:

alpha-TSE; alpha-tocopheryloxybutyric acid

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Vitamin E: 8680
        tocopheryloxybutyric acid: 7
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Vitamin E: 8680
        tocopheryloxybutyric acid: 7

Experts

1.	Asano, Ryuji: 2 articles (11/2003 - 08/2002)
2.	Hagiwara, Kiyokazu: 2 articles (11/2003 - 08/2002)
3.	Nishikawa, Kazuhiro: 2 articles (11/2003 - 08/2002)
4.	Satoh, Haruna: 2 articles (11/2003 - 08/2002)
5.	Yano, Tomohiro: 2 articles (11/2003 - 08/2002)
6.	Hagiwara, K: 2 articles (05/2001 - 11/2000)
7.	Ichikawa, T: 2 articles (05/2001 - 11/2000)
8.	Kumadaki, I: 2 articles (05/2001 - 11/2000)
9.	Otani, S: 2 articles (05/2001 - 11/2000)
10.	Yajima, S: 2 articles (05/2001 - 11/2000)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 08/01/2002 - "The present study was carried out to establish the usefulness of alpha-tocopheryloxybutyric acid (TE) as a chemotherapeutic agent for human breast cancer. " 11/10/2003 - "alpha-Tocopheryloxybutyric acid enhances necrotic cell death in breast cancer cells treated with chemotherapy agent." 08/01/2002 - "Induction of apoptosis in a human breast cancer cell overexpressing ErbB-2 receptor by alpha-tocopheryloxybutyric acid."
2.	Carcinogenesis 05/01/2001 - "The suppression of ornithine decarboxylase expression and cell proliferation at the promotion stage of lung tumorigenesis in mice by alpha-tocopheryloxybutyric acid." 11/01/2000 - "In order to address this question, we examined the inhibitory effect of alpha-tocopheryloxybutyric acid (TSE), an ether derivative of vitamin E that cannot act as an antioxidant in vivo, on cell proliferation and the activation of Erk during promotion of lung tumorigenesis. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2007 - "Alpha-vitamin E derivative, RRR-alpha-tocopheryloxybutyric acid inhibits the proliferation of prostate cancer cells." 01/01/2007 - "To investigate the activity of RRR-alpha-tocopheryloxybutyric acid (TOB), an ether analog of RRR-alpha-tocopheryl succinate (VES), in prostate cancer cells. "
4.	Neoplasms (Cancer) 04/10/1998 - "The nonhydrolysable tocopherol ether analog, d-alpha-tocopheryloxybutyric acid (TSE), and its tocopherol ester counterpart, d-alpha-tocopheryl hemisuccinate (TS), have been shown to possess anti-tumor activity. "
5.	Leukemia 07/01/1994 - "Selective inhibition of leukemia cell proliferation (identical to that noted for CS and TS) was also observed following the treatment of cells with the nonhydrolyzable ether forms of CS (cholesteryloxybutyric acid) and TS (alpha-tocopheryloxybutyric acid). "

Related Drugs and Biologics

1.	Ether (Diethyl Ether)
2.	Vitamin E
3.	Tocopherols (Tocopherol)
4.	Succinic Acid (Succinate)
5.	ErbB-2 Receptor
6.	Ornithine Decarboxylase (Decarboxylase, Ornithine)
7.	Esters
8.	Antioxidants
9.	Acids

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)