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Caspin

a 45 kDa collagen-associated serpin, produced by colon adenocarcinoma cells; amino acid sequence in first source; GenBank D87975

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Serpins: 906
    - Caspin: 3
- Peptides: 82426
  - Serpins: 906
    - Caspin: 3
Chemical Actions and Uses
- Pharmacologic Actions: 160
  - Molecular Mechanisms of Pharmacological Action: 24
    - Enzyme Inhibitors: 1659
      - Protease Inhibitors: 6291
        Serine Proteinase Inhibitors: 1371
        Serpins: 906
        Caspin: 3

Experts

1.	Assadi, Farahnak: 1 article (01/2020)
2.	Daniali, Seyede Shahbanoo: 1 article (01/2020)
3.	Esmaeil Motlagh, Mohammad: 1 article (01/2020)
4.	Heshmat, Ramin: 1 article (01/2020)
5.	Kelishadi, Roya: 1 article (01/2020)
6.	Qorbani, Mostafa: 1 article (01/2020)
7.	Yazdi, Mayram: 1 article (01/2020)
8.	Blacque, Oliver E: 1 article (03/2002)
9.	Worrall, D Margaret: 1 article (03/2002)

Related Diseases

1.	Neoplasms (Cancer) 06/12/1998 - "These findings suggest that caspin/pigment epithelium-derived factor/early population doubling level cDNA-1 is a novel factor that might play a crucial role in embryogenesis and tumor metastasis through binding to the extracellular matrix." 03/29/2002 - "Binding studies with isolated proteins showed interaction between recombinant maspin and types I and III collagen but not other collagen subtypes, a profile strikingly similar to mouse pigment epithelium-derived factor (caspin), which is similarly down-regulated in murine adenocarcinoma tumors and is a potent inhibitor of angiogenesis. "
2.	Adenocarcinoma 03/29/2002 - "Binding studies with isolated proteins showed interaction between recombinant maspin and types I and III collagen but not other collagen subtypes, a profile strikingly similar to mouse pigment epithelium-derived factor (caspin), which is similarly down-regulated in murine adenocarcinoma tumors and is a potent inhibitor of angiogenesis. "
3.	Retinoblastoma (Glioblastoma, Retinal) 06/12/1998 - "Caspin also demonstrated high homology with human pigment epithelium-derived factor/early population doubling level cDNA-1, which reportedly induces neuronal differentiation of human retinoblastoma cells and is expressed in association with G0 growth arrest. "
4.	Neoplasm Metastasis (Metastasis) 06/12/1998 - "These findings suggest that caspin/pigment epithelium-derived factor/early population doubling level cDNA-1 is a novel factor that might play a crucial role in embryogenesis and tumor metastasis through binding to the extracellular matrix."
5.	Hypertension (High Blood Pressure) 01/01/2020 - "Body mass index (BMI), waist circumference (WC), weight-height ratio (WHR), a body shape index (ABSI) and blood pressure were measured in 14 008 children and adolescents aged 7-18 years in a national school-aged survey CASPIN V. Hypertension (HTN) was defined according to the 2017 American Academy of Pediatrics guidelines, using the 95th percentile. "

Related Drugs and Biologics

1.	Collagen
2.	pigment epithelium-derived factor
3.	Proteins (Proteins, Gene)
4.	SERPIN-B5 (maspin)
5.	Serpins