dt(388) granulocyte-macrophage colony-stimulating factor

a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-machrophage colony-stimulating factor

Also Known As:

dt(388)-gm-csf

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Pentosyltransferases
        ADP Ribose Transferases: 198
        Diphtheria Toxin: 708
        dt(388) granulocyte-macrophage colony-stimulating factor: 2
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Hematopoietic Cell Growth Factors: 13
      - Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112
        dt(388) granulocyte-macrophage colony-stimulating factor: 2
- Biological Toxins: 20
  - Bacterial Toxins: 814
    - Diphtheria Toxin: 708
      - dt(388) granulocyte-macrophage colony-stimulating factor: 2
Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Granulocyte-Macrophage Colony-Stimulating Factor: 8112
        dt(388) granulocyte-macrophage colony-stimulating factor: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112
        dt(388) granulocyte-macrophage colony-stimulating factor: 2
  - Glycoproteins: 24834
    - Colony-Stimulating Factors: 1599
      - Granulocyte-Macrophage Colony-Stimulating Factor: 8112
        dt(388) granulocyte-macrophage colony-stimulating factor: 2
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Hematopoietic Cell Growth Factors: 13
        Colony-Stimulating Factors: 1599
        Granulocyte-Macrophage Colony-Stimulating Factor: 8112
        dt(388) granulocyte-macrophage colony-stimulating factor: 2

Experts

1.	Case, L Douglas: 1 article (05/2002)
2.	Frankel, Arthur E: 1 article (05/2002)
3.	Hall, Philip D: 1 article (05/2002)
4.	Kreitman, Robert J: 1 article (05/2002)
5.	Powell, Bayard L: 1 article (05/2002)
6.	Cabot, M C: 1 article (09/2001)
7.	Frankel, A E: 1 article (09/2001)
8.	Han, T Y: 1 article (09/2001)
9.	Kaufmann, S H: 1 article (09/2001)
10.	Kottke, T J: 1 article (09/2001)

Related Diseases

1.	Diphtheria 05/01/2002 - "We tested the safety and efficacy of a diphtheria fusion protein [diphtheria toxin (DT)388 granulocyte-macrophage colony-stimulating factor (GMCSF)] directed against the GMCSF receptor that is strongly expressed by leukemic blasts. "
2.	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 09/15/2001 - "DT(388)-GM-CSF, a targeted fusion toxin constructed by conjugation of human granulocyte-macrophage colony-stimulating factor (GM-CSF) with the catalytic and translocation domains of diphtheria toxin, is presently in phase I trials for patients with resistant acute myeloid leukemia. "
3.	Myeloid Leukemia (Leukemia, Myelocytic) 09/15/2001 - "HL-60/VCR, a multidrug-resistant human myeloid leukemia cell line, and wild-type HL-60 cells were used to study the impact of DT(388)-GM-CSF on metabolism of ceramide, a modulator of apoptosis. "

Related Drugs and Biologics

1.	Diphtheria Toxin
2.	Proteins (Proteins, Gene)
3.	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)
4.	Ceramides