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1-oxa-3,8-diazaspiro(4.5)decan 2-one

a diazaspiro compound with potent inhibitory effect on neuronal Na and Ca movement and stimulatory action on nerve growth factor production

Also Known As:

RGH 2716; RGH-2716

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 1-oxa-3,8-diazaspiro(4.5)decan 2-one: 1
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 1-oxa-3,8-diazaspiro(4.5)decan 2-one: 1

Related Diseases

1.	Cognitive Dysfunction 03/15/1998 - "The present results make RGH-2716 an interesting compound for the treatment of cognitive disorders."
2.	Memory Disorders (Memory Loss) 03/15/1998 - "Effect of RGH-2716 on learning and memory deficits of young and aged rats in water-labyrinth."
3.	Retrograde Amnesia 03/15/1998 - "In retrograde amnesia model RGH-2716 (3 mg/kg p.o.) significantly ameliorated consolidation process and retrieval of information impaired by SCOP or DIA. "
4.	Amnesia (Dissociative Amnesia) 03/15/1998 - "RGH-2716 is a novel 1-oxa-3,8-diazaspiro[4.5] decan 2-one, which was published to have potent inhibitory effect on neuronal Na and Ca movement and stimulatory action on nerve growth factor (NGF)-production, as well as to show significant antiamnesic activity in experimental amnesia models. "

Related Drugs and Biologics

1.	Nerve Growth Factor (NGF)
2.	4- (4- dihexadecylaminostyryl)- N- methylpyridium (DiA)