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1- (2- amino- 4- methanesulfonamidophenoxy)- 2- (N- (3,4- dimethoxyphenethyl)- N- methylamino)ethane

a class III antiarrhythmic agent; structure given in first source

Also Known As:

KCB 328; KCB-328

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Chandra, Parag: 1 article (09/2004)
2.	Danilo, Peter: 1 article (09/2004)
3.	Kim, Hak-Yeop: 1 article (09/2004)
4.	Lee, Kiho: 1 article (09/2004)
5.	Rosen, Michael R: 1 article (09/2004)
6.	Rosen, Tove S: 1 article (09/2004)
7.	Yeom, Zi-Ho: 1 article (09/2004)
8.	Al-Kandari, F: 1 article (07/2001)
9.	Feld, G K: 1 article (07/2001)
10.	Gupta, A: 1 article (07/2001)

Related Diseases

1.	Cardiac Arrhythmias (Arrythmia) 01/01/2001 - "C & C Research Labs is investigating the class III antiarrhythmic KCB-328 as a potential treatment for heart arrhythmia [310688]. " 08/01/1998 - "Antiarrhythmic effects of a novel class III drug, KCB-328, on canine ventricular arrhythmia models." 08/01/1998 - "After MS-551 or KCB-328 administration, the adrenaline injection was repeated and the interval between the injection and the occurrence of arrhythmia (latent interval), the changes in arrhythmic ratio (as calculated by dividing the number of ventricular premature contraction by the number of the total heart rate) and the severity of arrhythmia were observed. " 08/01/1998 - "We investigated the proarrhythmic effects of MS-551 and KCB-328, class III antiarrhythmic drugs using adrenaline-induced arrhythmia models in halothane anaesthetized, closed-chest dogs. "
2.	Ventricular Tachycardia 08/01/1998 - "Under the halothane anesthesia, KCB-328 alone showed proarrhythmic effects [i.e., induction of ventricular premature contractions (VPCs)], but it did not induce a more severe effect such as torsades de pointes-type ventricular tachycardia (VT). "
3.	Torsades de Pointes (Torsade de Pointes) 08/01/1998 - "Under the halothane anesthesia, KCB-328 alone showed proarrhythmic effects [i.e., induction of ventricular premature contractions (VPCs)], but it did not induce a more severe effect such as torsades de pointes-type ventricular tachycardia (VT). "
4.	Ventricular Fibrillation 08/01/1998 - "KCB-328, in an infusion of 1 mg/kg/h, suppressed the occurrence of fatal ventricular fibrillation (VF) induced by coronary ligation and reperfusion under either halothane anesthesia (p < 0.05) or pentobarbital anesthesia (p < 0.05). "
5.	Myocardial Infarction 08/01/1998 - "KCB-328, in an intravenous infusion of 0.5 mg/kg/30 min, prolonged the QTc interval only 11%, but had antiarrhythmic effects on the reentry arrhythmias induced by PES (12 of 12 dogs with old myocardial infarction; p < 0.05). "

Related Drugs and Biologics

1.	Halothane (Fluothane)
2.	Anti-Arrhythmia Agents
3.	Propafenone (Rythmol)
4.	Pentobarbital (Nembutal)
5.	Epinephrine (Adrenaline)
6.	nifekalant
7.	dofetilide (Tikosyn)

Related Therapies and Procedures

1.	Ligation
2.	Intravenous Infusions
3.	Anesthesia