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CHF 1024

a DA2-dopaminergic receptor / alpha 2 adrenoceptor agonist

Also Known As:

5,6-dihydroxy-2-methyl-aminotetraline hydrochloride; CHF-1024

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        CHF 1024: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - CHF 1024: 5

Experts

1.	Razzetti, Roberta: 2 articles (02/2006 - 11/2003)
2.	Berni, Roberta: 1 article (02/2006)
3.	Bocchi, Leonardo: 1 article (02/2006)
4.	Cacciani, Francesca: 1 article (02/2006)
5.	Lapucci, Silvia: 1 article (02/2006)
6.	Musso, Ezio: 1 article (02/2006)
7.	Pastore, Fiorella: 1 article (02/2006)
8.	Savi, Monia: 1 article (02/2006)
9.	Stilli, Donatella: 1 article (02/2006)
10.	Zaniboni, Massimiliano: 1 article (02/2006)

Related Diseases

1.	Ischemia 11/01/2003 - "CHF-1024, perfused through the heart for 15 min before ischemia at different molar concentrations (1-100 nM), significantly improved left ventricle developed pressure during reperfusion, and normalized left ventricular end-diastolic pressure and coronary perfusion pressure. "
2.	Atrial Remodeling 02/01/2006 - "Effects of the alpha2-adrenergic/DA2-dopaminergic agonist CHF-1024 in preventing ventricular arrhythmogenesis and myocyte electrical remodeling, in a rat model of pressure-overload cardiac hypertrophy."
3.	Ventricular Dysfunction 11/01/2003 - "These events were concomitant with maintenance of a higher production of 6-keto-prostaglandin F1alpha The ability of CHF-1024 to improve postischemic ventricular dysfunction was correlated with a dose-dependent inhibition of the release of both norepinephrine (NE), from sympathetic nerve endings, and TNF-alpha from cardiac tissue. "
4.	Left Ventricular Dysfunction 04/01/1998 - "In conclusion, CHF-1024 infused for 1 month to rats with LV dysfunction reduced heart rate, NE spillover, and collagen deposition, without unwanted effects, only appearing at the higher dose. "
5.	Hypotension (Low Blood Pressure) 09/01/1999 - "When CHF-1024 or metoprolol was given with delapril, sympathetic activation decreased with no unwanted effects, such as excessive hypotension."

Related Drugs and Biologics

1.	Adrenergic Agents (Adrenergic Drugs)
2.	Norepinephrine (Noradrenaline)
3.	Collagen
4.	Dopamine Agonists (Dopamine Agonist)
5.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
6.	Metoprolol (Toprol-XL)
7.	Captopril (Capoten)
8.	delapril