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10,10- bis(4- pyridinylmethyl)- 9(10H)- anthracenone

neurotransmitter release enhancer and potassium channel blocker; structure given in first source

Also Known As:

XE 991, anthracenone; XE-991; XE991 cpd

Networked: 9 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Anthracenes: 12
        10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone: 9
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Anthracenes: 12
    - 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone: 9

Experts

1.	Cai, Jie: 2 articles (03/2015 - 03/2013)
2.	Fang, Dong: 2 articles (03/2015 - 03/2013)
3.	Xing, Guo-Gang: 2 articles (03/2015 - 03/2013)
4.	Berg, Torill: 1 article (01/2016)
5.	Li, Song: 1 article (03/2015)
6.	Liu, Xiao-Dan: 1 article (03/2015)
7.	Ren, Juan: 1 article (03/2015)
8.	Han, Ji-Sheng: 1 article (03/2013)
9.	Liu, Min: 1 article (03/2013)
10.	Wan, You: 1 article (03/2013)

Related Diseases

1.	Tachycardia (Tachyarrhythmias) 01/01/2016 - "XE-991 augmented the initial 3,4-DAP-induced bradycardia and eliminated the late tachycardia in SHR, but not in WKY. "
2.	Dystonia (Limb Dystonia) 11/01/2006 - "Retigabine (10 mg kg(-1) i.p., 20 mg kg(-1) p.o.) and flupirtine (20 mg kg(-1) i.p.) significantly improved dystonia, while XE-991 caused a significant aggravation in the dt sz mutant. "
3.	Bradycardia 01/01/2016 - "XE-991 augmented the initial 3,4-DAP-induced bradycardia and eliminated the late tachycardia in SHR, but not in WKY. "
4.	Hypersensitivity (Allergy) 12/15/2022 - "We found that repeated application of XE-991, a specific KCNQ channel blocker, induced PIPN-like alterations in rats, including mechanical hypersensitivity and degeneration of peripheral nerves, as detected by both morphological and behavioral assays. " 03/01/2015 - "Furthermore, we discovered that blockade of KCNQ/M channels in the spinal cord by local administration of XE-991, a specific KCNQ/M channel blocker, caused a robust increase in excitability of dorsal horn WDR neurons, while, producing obvious pain hypersensitivity in normal rats. "
5.	Hyperalgesia 03/01/2013 - "Coincidently, we found that inhibition of KCNQ/M channels with XE-991 caused a robust increase in the excitability of small-sized DRG neurons and produced an obvious mechanical allodynia in normal rats. " 03/01/2015 - "On the contrary, activation of spinal KCNQ/M channels by retigabine, a selective KCNQ/M channel opener, not only inhibited the bone cancer‑induced hyperexcitability of dorsal horn WDR neurons, but also alleviated mechanical allodynia and thermal hyperalgesia in the bone cancer rats, while all of these effects of retigabine could be blocked by KCNQ/M-channel antagonist XE-991. " 03/01/2013 - "On the contrary, activation of the KCNQ/M channels with retigabine not only inhibited the hyperexcitability of these small DRG neurons, but also alleviated mechanical allodynia and thermal hyperalgesia in bone cancer rats, and all of these effects of retigabine could be blocked by KCNQ/M-channel antagonist XE-991. "

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4.	Antioxidants
5.	N- (6- Chloropyridin- 3- yl)- 3,4- difluorobenzamide
6.	linopirdine