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Description: neurotransmitter release enhancer; structure given in first source
Also Known As:| 1. | Tremor (Tremors)
05/01/1998
- "Although 5 mg/kg (p.o.) linopirdine does not lead to statistically significant increases in hippocampal extracellular acetylcholine levels, 5 mg/kg (p.o.) XE991 leads to increases (maximal effect > 90% over baseline) which are sustained for 60 min. Moreover, DMP 543 at 1 mg/kg causes more than a 100% increase in acetylcholine levels with the effect lasting more than 3 hr. At doses relevant to their release-enhancing properties, the only overt symptom consistently observed was tremor, possible via a cholinergic mechanism"
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| 2. | Alzheimer Disease (Alzheimer's Disease)
05/01/1998
- "These results suggest that XE991 and DMP 543 may prove to be superior to linopirdine as Alzheimer's disease therapeutics"
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| 2 Diseases and 1 more articles analyzed in the Research Interface, order at left... | |
| 1. | Acetylcholine (Acetylcholine Chloride)
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| 2. | linopirdine
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| 2 Drugs and Important Bio-Agents and 1 more articles analyzed in the Research Interface, order at left... | |
| 1. | Therapeutics
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| 1 Therapies and Procedures and 1 more articles analyzed in the Research Interface, order at left... | |
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