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Ac- aspartyl- glutamyl- valyl- aspartyl- aminomethylcoumarin

oligopeptide with coumarin inhibitor of cysteine proteinase

Also Known As:

Ac-DEVD-AMC; N-acetyl Asp-Glu-Val-Asp-7-amino-4-methylcoumarin; acetyl-DEVD-AMC

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Coumarins: 826
        Ac-aspartyl-glutamyl-valyl-aspartyl-aminomethylcoumarin: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Coumarins: 826
        Ac-aspartyl-glutamyl-valyl-aspartyl-aminomethylcoumarin: 2
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Ac-aspartyl-glutamyl-valyl-aspartyl-aminomethylcoumarin: 2

Related Diseases

1.	Hypoxia (Hypoxemia) 09/01/1999 - "In these experiments, caspase activity was detected with the fluorescence substrate Ac-Tyr-Val-Ala-Asp-7-amido-4-methyl coumarin (Ac-YVAD-AMC), which is preferentially cleaved by caspase 1. However, minimal caspase activity was detected with the fluorescence substrate Ac-Asp-Glu-Val-Asp-7-amido-4-methyl coumarin (Ac-DEVD-AMC), which is cleaved by caspases 2, 3, and 7. The present study in proximal tubules demonstrates that (1) caspase inhibition protects against necrotic injury by inhibition of hypoxia-induced caspase activity; and (2) caspase 1 may be the caspase involved. "
2.	Ischemia 10/15/1997 - "Moreover, an increase in CPP-32-like proteolytic activity was detected in hippocampal extracts 24 h after ischemia using the fluorogenic CPP-32 substrate Ac-DEVD-AMC. "

Related Drugs and Biologics

1.	Caspase 1 (ICE Protease)
2.	Caspases
3.	coumarin