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preproadrenomedullin

a precursor protein; amino acid sequence in first source

Also Known As:

preproAM

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Protein Precursors: 37
    - preproadrenomedullin: 6

Experts

1.	Kitamura, Kazuo: 2 articles (09/2011 - 06/2002)
2.	Kuwasako, Kenji: 2 articles (09/2011 - 06/2002)
3.	Hwang, Isabel S S: 2 articles (06/2007 - 01/2007)
4.	Tang, Fai: 2 articles (06/2007 - 01/2007)
5.	Chijiiwa, Kazuo: 1 article (09/2011)
6.	Hikosaka, Tomomi: 1 article (09/2011)
7.	Hoshiko, Shinri: 1 article (09/2011)
8.	Inatsu, Haruhiko: 1 article (09/2011)
9.	Nagata, Sayaka: 1 article (09/2011)
10.	Tsuchiya, Kazuyo: 1 article (09/2011)

Related Diseases

1.	Starvation 06/01/2007 - "An up-regulation of preproAM gene expression was observed in the fundus after acute starvation, and in the pylorus after chronic starvation. " 06/01/2007 - "The present study suggests that the gene expression of preproadrenomedullin mRNA is differentially regulated by starvation in the different parts of the stomach." 06/01/2007 - "To investigate the effects of starvation on AM in the stomach, we studied the changes in gene expression of preproadrenomedullin (preproAM) and AM receptors by reverse transcription-polymerase chain reaction (RT-PCR), and tissue AM concentrations by radioimmunoassay (RIA) in the fundus and pylorus of the stomach of rats subjected to either acute (1-day) or chronic (4-day) starvation. "
2.	Shock 08/25/2009 - "In this study, we used techniques of in situ hybridization, immunohistochemistry, electric stimulation of the dorsal periaquaductal gray of the midbrain (dPAG) and microinjection to investigate the changes of preproadrenomedullin (ppADM) gene expression encoding adrenomedullin (ADM) and ADM-like immunoreactivity (ADM-IR) in the medulla oblongata, especially in the rostral ventrolateral medulla (rVLM) of the rats receiving foot-shock and noise stress for 5 d, and the potential role of ADM in cardiovascular component of defense response in the rVLM. "
3.	Vascular Remodeling 06/01/2002 - "Since aldosterone has been shown to be involved in vascular remodeling, we examined the effects of aldosterone on AM and PAMP secretion and preproAM gene expression in human aortic vascular smooth muscle cells (VSMC). " 06/01/2002 - "Both adrenomedullin (AM) and pro-adrenomedullin N-terminal 20 peptide (PAMP), processed from the same precursor of prepro-adrenomedullin (preproAM), have differential biological properties; AM dilates blood vessels and presumably affects the vascular remodeling, while PAMP inhibits catecholamine secretion. "
4.	Pheochromocytoma 07/01/1996 - "Adrenomedullin (AM), a potent and novel vasodilator 52-residue peptide originally isolated from pheochromocytoma, is processed from a precursor molecule (preproAM) in which another unique 20-residue sequence, termed proadrenomedullin N-terminal 20 peptide (PAMP), exists. "
5.	Neoplasms (Cancer) 09/01/2011 - "Moreover, real-time quantitative RT-PCR showed that the expression levels of preproAM (+548%), preproAM2/IMD (+2674%), calcitonin receptor-like receptor (CLR) (+518%), receptor activity modifying protein (RAMP)2 (+281%), RAMP3 (+178%), VEGF-A (+277%) and MMP-9 (+864%) mRNAs were significantly higher in cancer tissues than in the surrounding normal tissues, and there was a positive correlation between the gene expressions of MMP-9 and preproAM (r=0.352; p=0.005), but not with preproAM2/IMD (r=0.041, p=0.406). "

Related Drugs and Biologics

1.	Adrenomedullin
2.	Messenger RNA (mRNA)
3.	Peptides (Polypeptides)
4.	Pathogen-Associated Molecular Pattern Molecules
5.	preproadrenomedullin
6.	Calcitonin Receptor-Like Protein
7.	Receptor Activity-Modifying Proteins
8.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
9.	Vasodilator Agents (Vasodilators)
10.	DNA (Deoxyribonucleic Acid)