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1- methylpiperidine- 4- spiro- (2'- methylthiazoline)

a selective and efficacious M1 agonist no further information

Also Known As:

AF 150(S); AF-150(S)

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - 1-methylpiperidine-4-spiro-(2'-methylthiazoline): 2
  - Piperidines: 17
    - 1-methylpiperidine-4-spiro-(2'-methylthiazoline): 2
Organic Chemicals: 133
- Sulfur Compounds: 278
  - Thiazoles: 392
    - 1-methylpiperidine-4-spiro-(2'-methylthiazoline): 2

Related Diseases

1.

Memory Disorders (Memory Loss)

05/01/1998 - "In the present study, we examined whether the memory deficits and brain cholinergic deficiency of apoE-deficient mice can be ameliorated by the M1-selective agonist 1-methylpiperidine-4-spiro-(2'-methylthiazoline), [AF150(S)]. "
01/01/1999 - "Furthermore, treatment of apoE-deficient mice with the M1 selective agonist 1-methylpiperidine-4-spiro-(2'-methylthiazoline) [AF150(S)] abolishes their memory deficits and results in recovery of their brain cholinergic markers. "

Related Drugs and Biologics

1.	Cholinergic Agents (Cholinergics)
2.	Apolipoproteins E (ApoE)