FR 143430

a cytokine suppressive agent; structure given in first source

Also Known As:

2-(4-fluorophenyl)-4,5,6,7-tetrahydro-3-(4-pyridyl)pyrazolo(1,5-a)pyrimidine monohydrochloride; FR-143430; FR143430

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - FR 143430: 1
  - Pyrimidines: 510
    - FR 143430: 1

Related Diseases

1.	Neoplasms (Cancer) 01/01/1998 - "Overall, this study demonstrated that the cachexia induced by colon26 was alleviated by the injection of FR143430 into the tumor in sufficient quantity, without any effect on tumor growth, suggesting the potential utility of cytokine suppressive agents e for the treatment of cancer cachexia." 01/01/1998 - "Nevertheless, treatment with FR143430 (0.1 to lmg) into the tumor resulted in the attenuation of the reduction in body weight, food intake, epididymal fat and carcass weight, the decrease in the circulating levels of triglyceride and glucose, and the increase in the circulating levels of total cholesterol, non esterified free fatty acid (NEFA) and total protein, which were induced by the presence of the tumor. "
2.	Cachexia 01/01/1998 - "However, oral treatment with FR143430 failed to show an inhibitory effect on cachexia induction. " 01/01/1998 - "Overall, this study demonstrated that the cachexia induced by colon26 was alleviated by the injection of FR143430 into the tumor in sufficient quantity, without any effect on tumor growth, suggesting the potential utility of cytokine suppressive agents e for the treatment of cancer cachexia." 01/01/1998 - "Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice." 01/01/1998 - "In this study the effect of FR143430, (2-(4-fluorophenyl)-4, 5, 6, 7-tetrahydro-3-(4-pyridyl)pyrazolo[1, 5-a]pyrimidine monohydrochloride), an inhibitor of Interleukin-1 and Tumor necrosis factor-a (TNF- a), on adenocarcinoma colon26-induced cachexia was investigated in mice. "
3.	Adenocarcinoma 01/01/1998 - "Effect of FR143430, a novel cytokine suppressive agent, on adenocarcinoma colon26-induced cachexia in mice." 01/01/1998 - "In this study the effect of FR143430, (2-(4-fluorophenyl)-4, 5, 6, 7-tetrahydro-3-(4-pyridyl)pyrazolo[1, 5-a]pyrimidine monohydrochloride), an inhibitor of Interleukin-1 and Tumor necrosis factor-a (TNF- a), on adenocarcinoma colon26-induced cachexia was investigated in mice. "
4.	Body Weight (Weight, Body) 01/01/1998 - "Nevertheless, treatment with FR143430 (0.1 to lmg) into the tumor resulted in the attenuation of the reduction in body weight, food intake, epididymal fat and carcass weight, the decrease in the circulating levels of triglyceride and glucose, and the increase in the circulating levels of total cholesterol, non esterified free fatty acid (NEFA) and total protein, which were induced by the presence of the tumor. "

Related Drugs and Biologics

1.	Cytokines
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-1 (Interleukin 1)
4.	pyrimidine
5.	Triglycerides (Triacylglycerol)
6.	Proteins (Proteins, Gene)
7.	Glucose (Dextrose)
8.	Nonesterified Fatty Acids (NEFA)
9.	Cholesterol