brinzolamide (Azopt)

an antiglaucoma agent

Also Known As:

Azopt; (R)-4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide 1,1-dioxide; 2H-thieno(3,2-E)-1,2-thiazine-6-sulfonamide, 4-(ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-, 1,1-dioxide, (R)-

Networked: 196 relevant articles (34 outcomes, 53 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - brinzolamide: 196
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - brinzolamide: 196
  - Thiazines: 3
    - brinzolamide: 196
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - brinzolamide: 196

Experts

1.	Goldberg, Ivan: 5 articles (01/2021 - 01/2012)
2.	Supuran, Claudiu T: 4 articles (04/2020 - 03/2003)
3.	Holló, Gábor: 4 articles (02/2020 - 06/2008)
4.	Kiuchi, Yoshiaki: 3 articles (11/2021 - 01/2012)
5.	Hubatsch, Douglas: 3 articles (01/2021 - 09/2014)
6.	Hubatsch, Douglas A: 3 articles (05/2016 - 01/2015)
7.	Realini, Tony: 3 articles (05/2016 - 01/2013)
8.	Aung, Tin: 3 articles (01/2015 - 04/2009)
9.	Nguyen, Quang H: 3 articles (01/2014 - 01/2013)
10.	Whitson, Jess T: 3 articles (04/2013 - 06/2008)

Related Diseases

1.	Open-Angle Glaucoma (Glaucoma, Open Angle) 01/01/2012 - "This study suggests that brinzolamide may be safely added to TTFC therapy to provide further significant reduction in IOP patients with ocular hypertensive or primary open-angle glaucoma." 02/01/2000 - "This study was performed to establish the long-term safety and efficacy of brinzolamide 1.0% two and three times daily for primary open-angle glaucoma and ocular hypertension. " 01/01/2000 - "A multicenter, double-masked, placebo-controlled, parallel trial was conducted to evaluate the optimal intraocular pressure (IOP)-lowering concentration and ocular tolerability of topically administered brinzolamide (0.3%, 1%, 2%, and 3%) in patients with primary, open-angle glaucoma or ocular hypertension. " 09/01/2008 - "Brinzolamide has been introduced to treat ocular hypertension and primary open-angle glaucoma. " 01/01/2003 - "Brinzolamide : a review of its use in the management of primary open-angle glaucoma and ocular hypertension."
2.	Ocular Hypertension (Glaucoma, Suspect) 10/01/2003 - "This study examines the mechanisms by which brinzolamide reduces intraocular pressure (IOP) in healthy rabbits and in monkeys with unilateral ocular hypertension. " 02/01/2000 - "This study was performed to establish the long-term safety and efficacy of brinzolamide 1.0% two and three times daily for primary open-angle glaucoma and ocular hypertension. " 01/01/2000 - "A multicenter, double-masked, placebo-controlled, parallel trial was conducted to evaluate the optimal intraocular pressure (IOP)-lowering concentration and ocular tolerability of topically administered brinzolamide (0.3%, 1%, 2%, and 3%) in patients with primary, open-angle glaucoma or ocular hypertension. " 09/01/2008 - "Brinzolamide has been introduced to treat ocular hypertension and primary open-angle glaucoma. " 01/01/2003 - "Brinzolamide : a review of its use in the management of primary open-angle glaucoma and ocular hypertension."
3.	Glaucoma 06/01/2008 - "Efficacy of brinzolamide and levobetaxolol in pediatric glaucomas: a randomized clinical trial." 01/01/2019 - "Randomized controlled trials of brinzolamide as add-on to PGAs or β-blocker for glaucoma and OHT were included. " 12/15/2023 - "The research work aimed to develop a robust sustained release biocompatible brinzolamide (BRZ)-loaded ocular inserts (MeltSerts) using hot-melt extrusion technology with enhanced solubility for glaucoma management. " 11/01/2022 - "Mucoadhesive brinzolamide-loaded nanofibers for alternative glaucoma treatment." 03/01/2022 - "A 33-year-old decoration worker was diagnosed as the absolute stage of right eye glaucoma in the local hospital and was treated with cataprolol and brinzolamide eye liquid to reduce intraocular pressure. "
4.	Cataract (Cataracts) 03/01/2008 - "In clinical trials, brinzolamide 1% has been shown to be able to reduce IOP when administered as monotherapy, adjunctive therapy or after cataract surgery. " 01/01/2013 - "The fixed combination brinzolamide-timolol can effectively reduce IOP after cataract surgery." 01/01/2013 - "To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure (IOP) after cataract surgery. " 03/01/2020 - "To evaluate the effectiveness of brinzolamide-brimonidine fixed combination to control the intraocular pressure elevation throughout the first 24 h following uncomplicated phacoemulsification cataract surgery. " 09/01/2013 - "A single dose of brinzolamide-timolol fixed combination after phacoemulsification cataract surgery prevented a significant intraocular pressure increase during the first 24 h postoperatively."
5.	Retinoschisis (Retinoschisis, Juvenile) 04/01/2013 - "Topical brinzolamide for foveal schisis in juvenile retinoschisis." 09/01/2020 - "Topical brinzolamide therapy may lead to improvement of papillomacular retinoschisis." 01/01/2020 - "The aim of this study was to report the outcome of topical brinzolamide 1% treatment on macular cystoid lesions resembling retinoschisis in 4 patients diagnosed with posterior microphthalmia. " 09/01/2020 - "Her medication was switched from topical latanoprost to brinzolamide, resulting in gradual improvement in the papillomacular retinoschisis thereafter. " 09/01/2020 - "His medication was switched from topical tafluprost/timolol to brinzolamide, resulting in gradual improvement in the papillomacular retinoschisis and foveal detachment thereafter. "

Related Drugs and Biologics

1.	Timolol (Blocadren)
2.	Brimonidine Tartrate (Alphagan)
3.	brinzolamide (Azopt)
4.	dorzolamide (Trusopt)
5.	Travoprost (Travatan)
6.	Latanoprost (Xalatan)
7.	Suspensions
8.	Ophthalmic Solutions (Eye Drops)
9.	Synthetic Prostaglandins (Prostaglandin Analogues)
10.	Solutions

Related Therapies and Procedures

1.	Therapeutics
2.	Phacoemulsification
3.	Flowmeters
4.	Hydrophilic Contact Lenses (Hydrophilic Contact Lens)
5.	Drug Therapy (Chemotherapy)