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BIM 23197

Also Known As:
BIM-23197; N-(N'-(2-hydroxyethyl)-piperazinyl)-2-ethylsulfonyl-Phe-Cys-Tyr-Trp-Lys-Abu-Cys-Thr-NH2 disulfide; N-(N'-(2-hydroxyethyl)piperazinyl)-2-ethylsulfonyl-phenylalanyl-cysteinyl-tyrosyl-tryptophyl-lysyl-2-aminobutanoyl-cysteinyl-threoninamide disulfide
Networked: 5 relevant articles (0 outcomes, 3 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Enjalbert, A: 2 articles (01/2001 - 02/2000)
2. Jaquet, P: 2 articles (01/2001 - 02/2000)
3. Gunz, G: 2 articles (01/2001 - 02/2000)
4. Fina, F: 2 articles (01/2001 - 02/2000)
5. Culler, M D: 2 articles (01/2001 - 02/2000)
6. Saveanu, A: 2 articles (01/2001 - 02/2000)
7. Moreau, J P: 2 articles (01/2001 - 02/2000)
8. Cap, J: 1 article (06/2003)
9. Suba, P: 1 article (06/2003)
10. Marek, J: 1 article (06/2003)

Related Diseases

1. Neoplasms (Cancer)
01/01/2001 - "In these tumors the suppression of GH release was similarly achieved at picomolar ranges by octreotide, BIM-23197, and BIM-23244 (EC(50) = 25 +/- 15, 3 +/- 2, and 3 +/- 3 pmol/L, respectively). "
04/01/1998 - "Based on higher plasma levels, greater distribution to target tissues and longer in vivo stability, BIM-23190 and BIM-23197 may prove to be superior to BIM-23014 for the treatment of acromegaly and some types of cancer."
02/01/2000 - "In the present study the quantitative expression of messenger ribonucleic acid (mRNA) for the 5 SSTR subtypes and the inhibitory effects of SRIF14; SRIF28; octreotide; the SSTR2-preferential analog, BIM-23197; and the SSTR5-preferential analog, BIM-23268, on GH and PRL secretion were analyzed in cells cultured from 15 acromegalic tumors. "
09/01/1999 - "The present study examines the quantitative profile of SSTRs messenger ribonucleic acid (mRNA) in 10 PRL-secreting tumors and correlates the expression with the ability of native somatostatins (SS14 and SS28), SSTR2 preferential analogs (octreotide and BIM-23197), and the SSTR5 preferential analog BIM-23268 to suppress PRL secretion. "
01/01/2001 - "In the present study we quantified SSTR2 and SSTR5 mRNA expression and the GH-suppressive effects of somatostatin-14; octreotide; a SSTR2-preferential compound, BIM-23197; a SSTR5-preferential compound, BIM-23268; and a new SSTR2- and SSTR5-bispecific compound, BIM-23244, in GH-secreting tumors classified as either full responders to octreotide (n = 5) or partially sensitive to octreotide (n = 5). "
2. Adenoma (Adenomas)
3. Acromegaly

Related Drugs and Biologics

1. BIM 23268
2. Octreotide (Sandostatin)
3. Messenger RNA (mRNA)
4. RNA (Ribonucleic Acid)
5. harpin (messenger)
6. Somatostatin (Somatotropin Release-Inhibiting Factor)
7. BIM-23244
8. tranilast (N 5')
9. BIM 23190
10. lanreotide (Somatuline)