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9- ((cis- 1,2- bis(hydroxymethyl)cycloprop- 1- yl)methyl)guanine

acyclic nucleoside; structure in first source

Also Known As:

A-5021; bhcm-guanine

Networked: 5 relevant articles (3 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purinones: 2
        Hypoxanthines: 1
        Guanine: 1793
        9-((cis-1,2-bis(hydroxymethyl)cycloprop-1-yl)methyl)guanine: 5

Experts

1.	Croubels, Siska: 1 article (02/2012)
2.	Glorieux, Sarah: 1 article (02/2012)
3.	Goris, Nesya: 1 article (02/2012)
4.	Nauwynck, Hans J: 1 article (02/2012)
5.	Neyts, Johan: 1 article (02/2012)
6.	Steukers, Lennert: 1 article (02/2012)
7.	Van de Walle, Gerlinde R: 1 article (02/2012)
8.	Vandekerckhove, Annelies P: 1 article (02/2012)
9.	Yang, Xiao-Yun: 1 article (02/2012)
10.	Deai, Tatsunori: 1 article (04/2008)

Related Diseases

1.	Infections 02/01/2012 - "Our data demonstrate that A-5021 is a potent inhibitor of EHV1 replication and may have potential for the treatment and/or prophylaxis of infections with this virus." 02/01/2001 - "When treatment was begun on day 1 or 2, A-5021 still afforded marked protection against the infection, whereas acyclovir was virtually devoid of any activity under these conditions. " 02/01/2001 - "When administered from day 0 to 4 p.i., A-5021 conferred complete protection against the infection (as assessed at 22 days p.i.), whereas acyclovir delayed virus induced mortality by only 5 days. " 06/01/1999 - "In mice with a cutaneous HSV-1 (KOS) infection, three times daily oral therapy with A-5021 at 25 mg/kg per day produced more significant reduction in severity of skin lesions than equivalent treatment with acyclovir or famciclovir. "
2.	Herpetic Keratitis 04/01/2008 - "To determine the efficacy of A-5021, a new analogue of acyclovir, on murine herpetic keratitis. "
3.	Herpesviridae Infections (Herpesvirus Infection) 02/01/2001 - "Our data underline that A-5021 may offer great promise for the treatment of herpesvirus infections."
4.	Lung Neoplasms (Lung Cancer) 04/01/2000 - "We demonstrated that A-5021 had potent cytotoxic activity equal to that of GCV against the retroviral vector-mediated HSV-TK gene-transduced lung cancer cell lines. "

Related Drugs and Biologics

1.	Acyclovir (Aciclovir)
2.	Famciclovir (Famvir)

Related Therapies and Procedures

1.	Therapeutics