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KR 30035

reverses multidrug resistance; structure in first source

Also Known As:

KR-30035

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Ethylamines: 5
    - Phenethylamines: 28
      - Verapamil: 6163
        KR 30035: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        Tetrahydronaphthalenes: 1
        KR 30035: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - Tetrahydronaphthalenes: 1
      - KR 30035: 2

Experts

1.	Choi, S U: 1 article (01/2000)
2.	Jung, N P: 1 article (01/2000)
3.	Lee, B H: 1 article (01/2000)
4.	Lee, C O: 1 article (01/2000)
5.	Park, S H: 1 article (01/2000)
6.	Shin, H S: 1 article (01/2000)
7.	Yi, K Y: 1 article (01/2000)
8.	Yoo, S E: 1 article (01/2000)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2000 - "Effects of KR-30035, a novel multidrug-resistance modulator, on the cardiovascular system of rats in vivo and on the cell cycle of human cancer cells in vitro." 01/01/2000 - "The present study was performed to evaluate the adverse effects of KR-30035, a multidrug-resistance modulator, on the cardiovascular system in vivo, along with its effect on paclitaxel-induced cell cycle arrest in cultured cancer cells. " 01/01/2000 - "In the presence of 10 microM KR-30035, paclitaxel (1 microM) when added to cultures of HCT15/CL02 human cancer cells greatly shifted the cell population from the G0/G1 phases towards G2/M phases (from 42.4, 30.3 and 27.3 to 14.6, 21.5 and 63.9% for the G0/G1, S and G2/M phases, respectively), with a similar magnitude to that of 10 microM verapamil (14.0, 15.7 and 70.3%, respectively). "
2.	Cardiotoxicity 02/01/1998 - "Additionally, the adverse cardiac toxicity of KR-30032 and KR-30035 was evaluated by measuring the changes of tension in isolated rat aorta and left ventricular pressure (LVP) in guinea pig heart. "

Related Drugs and Biologics

1.	Paclitaxel (Taxol)
2.	Verapamil (Calan)
3.	KR 30032