ultra-high molecular weight polyethylene (UHMWPE)

04/01/1998 - "Similarly, in tensile and fatigue tests of oxidized UHMWPE, there was a significant reduction in the ultimate tensile strength and in the fatigue resistance of specimens that had developed a subsurface band. "
09/01/2002 - "UHMWPE cable shows promise for this clinical application because of its greater tensile and fatigue strength. "
11/01/2004 - "The improved fatigue strength is attributed to the increase in plasticity of UHMWPE due to the lipophilic nature of alpha-T."
11/01/2004 - "The fatigue strength was improved by 58% for alpha-T-doped 100-kGy irradiated UHMWPE compared to irradiated and melted UHMWPE. "
01/01/2018 - "The morphology of wear debris is also an important factor to evaluate artificial joint materials, this study showed that the ULWPE wear debris gotten from the simulator had various different shapes, including spherical, block, tear, etc. The morphology of worn surface and wear debris analysis showed that wear mechanisms of ULWPE were adhesion wear, abrasive wear and fatigue wear and other wear forms, which were consistent with that of UHMWPE. "

01/01/2023 - "Across the studies, clinical results including revision rates, patient-reported outcome measurement scores, and the occurrence of osteolysis or radiolucent lines tended to be similar for AO-XLPE as compared to conventional UHMWPE or HXLPE controls. "
10/01/2015 - "This study aims to elucidate whether dendritic cells play a role in UHMWPE particle-induced osteolysis. "
01/01/2013 - "Further a UHMWPE-induced murine calvaria erosion model study was performed to assess the effects of PQQ on wear particle-induced osteolysis in vivo. "
08/01/2006 - "Cases of osteolysis from artificial discs are extremely rare, but hip and knee studies demonstrate the osteolytic potential and clinical concern of UHMWPE wear debris. "
02/01/2006 - "In conclusion, this study provides the evidence that EM inhibits the UHMWPE particles-induced inflammatory osteolysis in a murine model, and represents a promising therapeutic candidate for the prevention and treatment of AL."

08/01/2006 - "In conclusion, this study provides the evidence that UHMWPE particles induce strong inflammatory responses, but not associated with osteoclastic bone resorption in RANK(-/-) mice. "
01/01/2022 - "Consistent with this finding, 0.3%VE-UHMWPE debris showed the lowest osteolytic activity, as evidenced by the reduced bone resorption area, the degree of infiltration of inflammatory cells and the TRAP staining area. "
09/01/2014 - "There was a statistically significant difference between virgin (12.2%±8%) and VE-UHMWPE (3%±1.4%) groups in regards to bone resorption (P=0.005) and inflammatory fibrous tissue overlaying the calvaria (0.48 vs. 0.20, P<0.0001). "
08/01/2006 - "This indicates that RANK signaling is essential for UHMWPE particle-induced osteoclastic bone resorption, but does not participate in UHMWPE particle-induced inflammatory response."
08/01/2006 - "Consistent with the lack of osteoclastic activity shown by TRAP staining, no significant UHMWPE particle-induced bone resorption was found in RANK(-/-) mice. "

09/01/1998 - "Although T cells are not directly involved in UHMWPE particle induced inflammation, as shown by the T cell activation assays, the histological data from the mice studies clearly show differences in the amplitude of inflammation from animals with and without functional T cells. "
01/01/2023 - "The use of a UHMWPE implant fixed with interference screws to reconstruct the CdCL allowed a return to full function of the knee without complications, despite a persistent synovial inflammation and mild lameness for a 6-month period after the surgery. "
08/01/2014 - "Results showed that UHMWPE stimulation induced strong pouch tissue inflammation in CX3CR1(+/+) mice, as manifested by inflammatory cellular infiltration (mainly macrophages), pouch tissue proliferation, and increased gene expression of IL-1ß and TNFα. "
01/01/2013 - "However, in the soft wire group, both the surface of the greater trochanter under the fixation material and the penetration area around the fixation material showed an increased tendency toward a biological reaction, including inflammation and granulation tissue formation, as compared to the UHMWPE fiber cable group. "
08/01/2011 - "The presence of wear debris and inflammation in highly crosslinked UHMWPE revision tissues may contribute to early implant loosening."

02/01/2004 - "This study was aimed at investigating the role of friction gradients induced by localized coefficients of friction at both crystalline and amorphous nanoregions in PE, and crystalline and crosslinked nanoregions in crosslinked UHMWPE (XPE), in submicron wear debris generation. "
01/01/2019 - "The wear rate decreased significantly with increasing XPE content in UHMWPE/XPE and increasing radiation dose used in the XPE preparation. "
11/01/2010 - "Three different kinds of XPE and one conventional UHMWPE were tested over 5 million cycles in fixed-bearing knee designs. "
09/01/2009 - "The wear generated by the LCS knee design (XPE and UHMWPE) had a higher percentage fraction of particles >1microm in size (equivalent circle diameter). "
01/01/2018 - "Wear- and oxidation-resistant UHMWPE has been obtained previously by consolidating blends of pre-irradiated UHMWPE powders (XPE) into an unmodified polyethylene matrix (PE), where the improvement in wear rate depended on the radiation dose and fraction of XPE. "