|1.||Hu, Hui-Han: 1 article (03/2016)|
|2.||Leccia, Marie-Thérèse: 1 article (03/2016)|
|3.||Brice, Alexis: 1 article (03/2016)|
|4.||Descamps, Vincent: 1 article (03/2016)|
|5.||Soufir, Nadem: 1 article (03/2016)|
|6.||Andrieu-Abadie, Nathalie: 1 article (03/2016)|
|7.||Lebbé, Céleste: 1 article (03/2016)|
|8.||Michel, Laurence: 1 article (03/2016)|
|9.||Bressac-de-Paillerets, Brigitte: 1 article (03/2016)|
|10.||Mourah, Samia: 1 article (03/2016)|
|1.||Parkinson Disease (Parkinson's Disease)
08/01/2015 - "In this study, we surveyed all the available literature describing PARK2 gene/Parkin protein mutations found in Parkinson disease patients. "
06/01/2015 - "Previously, we isolated a mutant form of the Parkin protein (Q311R and A371T) from a Parkinson's disease patient. "
01/17/2014 - "Loss-of-function in the Parkin protein is thought to play a part in causing neuronal cell death in patients with Parkinson's disease. "
12/01/2007 - "The parkin protein as a therapeutic target in Parkinson's disease."
11/01/2004 - "[Parkin protein and molecular mechanism of Parkinson's disease]."
|2.||Schizophrenia (Dementia Praecox)
|3.||Parkinsonian Disorders (Parkinsonism)
05/29/2009 - "Missense mutations in park2, encoding the parkin protein, account for approximately 50% of autosomal recessive juvenile Parkinson disease (ARJP) cases. "
05/01/1999 - "Immunohistochemical and subcellular localization of Parkin protein: absence of protein in autosomal recessive juvenile parkinsonism patients."
09/01/2001 - "These data suggest that compound heterozygous parkin mutations and loss of parkin protein may lead to early-onset parkinsonism with Lewy body pathology, while a hemizygous mutation may confer increased susceptibility to typical Parkinson's disease."
04/30/2014 - "We found that in rotenone model of Parkinsonism, the expression/protein level of parkin and FMO1 were decreased accompanied by the activation of caspase 3. Blocking FMO activity by FMO inhibitor methimazole directly caused activation of caspase 3, meanwhile parkin protein level was decreased. "
|4.||Neurodegenerative Diseases (Neurodegenerative Disease)
11/26/2010 - "We therefore examined whether compensation of parkin protein prevents neurodegenerative disorders in mnd2 mice by generating parkin-transgenic (parkin-Tg) mnd2 mice. "
11/26/2010 - "Since parkin is a crucial protein for PD, the neurodegenerative disorder in mnd2 mice may be caused by parkin protein loss. "
01/14/2014 - "The E3 ubiquitin ligase activity of the parkin protein is implicated in playing a protective role against neurodegenerative disorders including Parkinson's, Huntington's, and Alzheimer's diseases. "
|1.||Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)
|4.||Caspase 3 (Caspase-3)
|5.||Proteasome Endopeptidase Complex (Proteasome)
|8.||Proteins (Proteins, Gene)
|10.||Amyloid (Amyloid Fibrils)