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5- benzylidenehydrazino- 2- methylpyridazin- 3(2H)- one
an interleukin-1 blocker; structure in first source
Also Known As:
CK 124; CK-124
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrazines: 379
5-benzylidenehydrazino-2-methylpyridazin-3(2H)-one: 1
Heterocyclic Compounds: 198
1-Ring Heterocyclic Compounds
Pyridazines: 11
5-benzylidenehydrazino-2-methylpyridazin-3(2H)-one: 1
Related Diseases
1.
Uveitis
02/01/1998 - "
Effective treatment of experimental uveitis with interleukin-1 blockers, CK 123 and CK 124.
"
02/01/1998 - "
In addition to anti-inflammation, CK 123 and CK 124 were also found to inhibit proliferation of fibroblast-like corneal and conjunctival cells, indicating that these compounds could be used not only as anti-uveitis agents but also as useful agents to prolong the functional period of aqueous humor outflow after trabeculectomy.
"
02/01/1998 - "
CK 123 and CK 124 are new IL-1 blockers which showed potent anti-uveitis actions that are more potent than the classic corticosteroid, prednisolone.
"
2.
Inflammation (Inflammations)
02/01/1998 - "
In addition to anti-inflammation, CK 123 and CK 124 were also found to inhibit proliferation of fibroblast-like corneal and conjunctival cells, indicating that these compounds could be used not only as anti-uveitis agents but also as useful agents to prolong the functional period of aqueous humor outflow after trabeculectomy.
"
Related Drugs and Biologics
1.
Interleukin-1 (Interleukin 1)
2.
4-benzylidenehydrazinocoumarin
3.
Prednisolone (Predate)
4.
Adrenal Cortex Hormones (Corticosteroids)
Related Therapies and Procedures
1.
Trabeculectomy (Trabeculoplasty)