|1.||Citrome, Leslie: 3 articles (07/2010 - 06/2009)|
|2.||Snead, O C: 3 articles (04/2001 - 01/2000)|
|3.||Hu, R Q: 3 articles (04/2001 - 01/2000)|
|4.||Crunelli, Vincenzo: 2 articles (10/2014 - 12/2003)|
|5.||Knudsen, Kai: 2 articles (07/2012 - 11/2005)|
|6.||Gibson, K M: 2 articles (01/2012 - 02/2011)|
|7.||Jakobs, C: 2 articles (01/2012 - 02/2011)|
|8.||Kantrowitz, Joshua T: 2 articles (07/2010 - 06/2009)|
|9.||Javitt, Daniel C: 2 articles (07/2010 - 06/2009)|
|10.||Colombo, Giancarlo: 2 articles (02/2008 - 02/2006)|
|1.||Substance Withdrawal Syndrome (Withdrawal Symptoms)
12/01/2004 - "Gamma-hydroxybutyric acid (GHB) is a naturally occurring substance in the brain, the administration of which has proved useful in the treatment of the opiate withdrawal symptoms in humans. "
09/01/2014 - "Gamma-hydroxybutyric acid-dependent persons with withdrawal symptoms often require forceful withdrawal treatment provided in psychiatric units. "
01/01/2010 - "Gamma-hydroxybutyric acid (GHB) can prevent and suppress withdrawal symptoms, and improve the medium-term abstinence rate. "
01/01/2009 - "To raise awareness among health care workers of the risk of withdrawal symptoms after longstanding and intense abuse of gamma-hydroxybutyric acid. "
04/01/2000 - "Gamma-hydroxybutyric acid treatment promptly reduced withdrawal symptoms in all patients and prevented alcohol withdrawal syndromes in 55% of cases. "
|2.||Alcoholism (Alcohol Abuse)
01/01/1999 - "The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies."
04/01/2000 - "However, a possible development of craving for the drug and the risk of abuse and physical dependence have been reported in subjects who used gamma-hydroxybutyric acid for different reasons, including alcoholism therapy. "
01/01/1999 - "Gamma-hydroxybutyric acid (GHB) is a drug recently utilized for alcoholism management. "
01/01/1999 - "Gamma-hydroxybutyric acid (GHB) is an emerging drug for alcoholism therapy. "
04/01/1997 - "Manageability and tolerability of gamma-hydroxybutyric acid in the medium term outpatient treatment of alcoholism."
04/01/1999 - "Gamma-hydroxybutyric acid is used outside the United States to treat narcolepsy. "
04/01/2000 - "Gamma-hydroxybutyric acid has established efficacy as an anesthetic agent, and preliminary evidence supports its utility in the treatment of alcohol dependence, opiate dependence, and narcolepsy."
04/01/2013 - "Gamma-hydroxybutyric acid (GHB; sodium oxybate) is approved for narcolepsy symptom treatment, and it is also abused. "
03/01/2013 - "Gamma-hydroxybutyric acid (GHB), well known as a party drug, especially in Europe, is also legally used (sodium oxybate, Xyrem(®)) to treat a rare sleep disorder, narcolepsy with cataplexy. "
10/01/2008 - "Gamma hydroxybutyric acid (GHB), an endogenous constituent of the mammalian brain, acts as i) a neurotransmitter or neuromodulator, ii) a medicine used for the treatment of narcolepsy and alcoholism, and iii) a drug illicitly used for its psychotropic effects. "
01/01/1991 - "Protective effects of gamma-hydroxybutyric acid on bioenergetic reactions were studied in brain of rats with ischemia using 31P-NMR spectroscopy in vivo. "
01/01/1991 - "Possible mechanisms of the gamma-hydroxybutyric acid effects on bioenergetic reactions in nervous tissue during ischemia are discussed."
01/01/1991 - "[The effect of gamma-hydroxybutyric acid on the reaction rate of phosphate-containing metabolites in the rat brain during ischemia estimated from (31)P-NMR spectroscopic data]."
01/01/1991 - "Intraperitoneal preadministration of gamma-hydroxybutyric acid at a dose of 400 mg/kg within 30-40 min before ischemia led to a decrease in the ATP pool in ischemic brain tissue, to alteration in the PCr/ATP ratio in the 31P-NMR spectrum, to prevention of Pi concentration increase and to increase in the intracellular acidosis development rate. "
11/01/2002 - "The present study investigates the activity of four gamma-hydroxybutyric acid amide analogues (BM-68, BM-74, BM-75 and BM-76) in two models of chemically induced seizures, i.e. "
01/01/1996 - "Antiabsence seizure activity of specific GABAB and gamma-Hydroxybutyric acid receptor antagonists."
09/01/1993 - "These findings confirm that gamma-hydroxybutyric acid-induced absence-like seizures originate from thalamocortical pathways and that the onset of gamma-hydroxybutyric acid-induced spike and wave discharges is directly related to the regulation of gamma-hydroxybutyric acid binding sites in those regions which constitute the involved thalamocortical loop."
09/01/1993 - "However, no significant change in [3H]gamma-hydroxybutyric acid binding was observed in this region nor was the CA3 field involved in the generation of spike and wave discharges during gamma-hydroxybutyric acid-induced absence-like seizures. "
04/01/1993 - "gamma-Hydroxybutyric acid (GHB) produces absence-like seizures when given to animals. "
|2.||Sodium Oxybate (gamma Hydroxybutyrate)
|6.||4-Butyrolactone (gamma Butyrolactone)
|7.||Ethanol (Ethyl Alcohol)
|2.||Drug Therapy (Chemotherapy)