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poly(trans- 1,2- diaminocyclohexane)platinum- carboxyamylose

Also Known As:

poly-plat

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - poly(trans-1,2-diaminocyclohexane)platinum-carboxyamylose: 2

Experts

1.	Aggarwal, Surinder K: 1 article (07/2002)
2.	Telgenhoff, Dale J: 1 article (07/2002)
3.	Aggarwal, S K: 1 article (07/2000)
4.	Burkitt, K: 1 article (07/2000)

Related Diseases

1.	Teratocarcinoma 07/01/2000 - "Murine peritoneal macrophages, human fibroblasts and human ovarian teratocarcinoma cells were treated with CDDP (10 micrograms/ml) and "poly-plat" (10 micrograms/ml) for 2 h and cultured for 2-96 h. " 07/01/2000 - "Based on our studies, we propose that "poly-plat" is more effective in activation of the macrophages and human fibroblasts in terms of IL-2, but not so with human ovarian teratocarcinoma cells." 07/01/2000 - "However, human ovarian teratocarcinoma cells didn't show any significant increase in IL-2 levels after "poly-plat" treatment and there was instead a decrease of 15% in cell numbers at 8 h. "
2.	Neoplasms (Cancer) 07/01/2002 - "These results demonstrate the ability of Poly-Plat to arrest the growth of tumor cells and activate macrophages to induce apoptosis in the cell lines tested." 07/01/2002 - "Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture. "
3.	Fibrosarcoma 07/01/2002 - "Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture. "
4.	Carcinoma (Carcinomatosis) 07/01/2002 - "Action of Cisplatin (cis-dichlorodiammine platinum II) and Poly-Plat [poly-[(trans-1,2-diaminocyclohexane) pla-tinum]-carboxyamylose] on tumor cells was examined using human fibrosarcoma (HT1080) and Walker rat carcinoma (WRC-256) in culture. "

Related Drugs and Biologics

1.	Interleukin-2 (IL2)
2.	Platinum
3.	Cisplatin (Platino)