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4- (phenylamino)- 7H- pyrrolo(2,3- d)pyrimidine

a potent protein-tyrosin kinase inhibitor; structure in first source

Also Known As:

CGP 59326A; CGP-59326 A

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - 4-(phenylamino)-7H-pyrrolo(2,3-d)pyrimidine: 1
  - Pyrimidines: 510
    - 4-(phenylamino)-7H-pyrrolo(2,3-d)pyrimidine: 1

Related Diseases

1.

Neoplasms (Cancer)

03/30/1998 - "Combination of CGP 59326A with cytotoxic agents resulted in tumor regression and cures. "
03/30/1998 - "CGP 59326A inhibited growth of human tumor xenografts expressing the EGF-R but showed little activity against EGF-R-negative xenografts. "
03/30/1998 - "In contrast to previously described inhibitors, CGP 59326A had potent and selective in vivo anti-tumor activity at well-tolerated doses against EGF-R-expressing tumors (e.g., ED50 of 0.78 to 1.5 mg/kg for inhibition of A431 tumor growth). "

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