|1.||Gold, Barry: 5 articles (07/2010 - 03/2002)|
|2.||Gold, B: 3 articles (06/2010 - 08/2001)|
|3.||Monti, Paola: 2 articles (07/2010 - 03/2008)|
|4.||Russo, Debora: 2 articles (07/2010 - 03/2008)|
|5.||Menichini, Paola: 2 articles (07/2010 - 03/2008)|
|6.||Fronza, Gilberto: 2 articles (07/2010 - 03/2008)|
|7.||Inga, Alberto: 2 articles (07/2010 - 03/2008)|
|8.||Perfumo, Chiara: 2 articles (07/2010 - 03/2008)|
|9.||Tentori, L: 2 articles (06/2010 - 08/2001)|
|10.||Graziani, G: 2 articles (06/2010 - 08/2001)|
|1.||Xeroderma Pigmentosum (Kaposi's Disease)
06/03/2004 - "The present study examines the role of the BER enzyme 3-alkyladenine DNA glycosylase (AAG) and the NER protein xeroderma pigmentosum group A (XPA) in protecting cerebellar neurons and astrocytes from chloroacetaldehyde (CAA) or the alkylating agent 3-methyllexitropsin (Me-Lex), which produce ethenobases or 3-methyladenine (3-MeA), respectively. "
|3.||DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes)
03/01/2008 - "To examine the contribution of translesion synthesis (TLS) DNA polymerases in the bypass of Me-lex-induced lesions, the REV3 and REV1 genes were independently deleted in the parental yeast strain and in different DNA repair-deficient derivatives: the nucleotide excision repair (NER)-deficient rad14, and the BER-deficient mag1 or apn1apn2 strains. "
07/01/2010 - "These results indicate that XRCC1 deficiency can lead to genomic instability even in the absence of an exogenous genotoxic insult and low levels of Me-lex-induced lesions, i.e., 3-mA and/or a BER intermediate, can exacerbate this instability."
07/01/2010 - "XRCC1 deficiency influences the cytotoxicity and the genomic instability induced by Me-lex, a specific inducer of N3-methyladenine."
03/01/2002 - "When concentrations of PARP-1 inhibitors (25 microM NU and 4 m M AB) that produced a twofold increase in Me-Lex cytotoxicity in tumor cells were compared, NU induced a less-pronounced increase in apoptosis in PBL treated with Me-Lex; (c) Me-Lex at concentrations that allowed cytogenetic analysis did not induce a significant number of SCE; (d) PARP-1 inhibitors provoked a dose-dependent increase in SCE, but 25 microM NU was devoid of genotoxic effects and did not significantly increase SCE in PBL treated with Me-Lex. "
03/01/2002 - "However, tumor cells with high MPG activity can be rendered susceptible to Me-Lex using poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. "
|2.||DNA Glycosylases (DNA Glycosylase)
|3.||Adenosine Diphosphate (ADP)
|6.||Poly Adenosine Diphosphate Ribose
|7.||DNA-Directed DNA Polymerase (Polymerases, DNA)
|8.||DNA (Deoxyribonucleic Acid)