Humatrix

tradename; myoepithelial matrical gel containing EGF, IGF-1, basement membrane and non-basement membrane molecules, including large amounts of chondroitin sulfate proteoglycan

Also Known As:

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Huang, Leaf: 1 article (12/2003)
2.	Lee, Pui-Yan: 1 article (12/2003)
3.	Li, Zhenhua: 1 article (12/2003)

Related Diseases

1.	Neoplasm Metastasis (Metastasis) 01/30/1998 - "Humatrix selectively stimulates the growth and tumorigenicity of human myoepithelial cell lines but inhibits invasion, angiogenesis and metastasis of other non-myoepithelial malignant cell lines. " 11/01/1997 - "HMS-X, HMS-3X, HMS-4X, and Humatrix inhibit tumor invasion and metastasis in severe combined immunodeficient mice (P < 0.001). "
2.	Wounds and Injuries (Trauma) 12/01/2003 - "We used a commercial wound dressing, Humatrix, either with or without DNA, to compare the therapeutic effect with the thermosensitive hydrogel. "
3.	Neoplasms (Cancer) 11/01/1997 - "HMS-X, HMS-3X, HMS-4X, and Humatrix inhibit tumor invasion and metastasis in severe combined immunodeficient mice (P < 0.001). " 11/01/1997 - "Humatrix, a gel that we have derived from HMS-X, inhibits tumor cell invasion (down to 25% +/- 10% of Matrigel control; P < 0.01), and our recently established human myoepithelial cell lines, HMS-1, HMS-3, and HMS-4, inhibit tumor cell invasion in cellular invasion (down to 42% +/- 7% of control; P < 0.05) and in conditioned media assays (down to 30% +/- 8% of control; P < 0.01). "
4.	Carcinoma (Carcinomatosis) 01/30/1998 - "Because of its myoepithelial origin Humatrix represents a more natural source of extracellular matrix molecules and bound factors that carcinoma cells encounter in vivo."

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Hydrogels
3.	Conditioned Culture Media
4.	DNA (Deoxyribonucleic Acid)
5.	matrigel