|1.||Dalkara, Turgay: 3 articles (03/2015 - 11/2009)|
|2.||Fernandez-Megia, Eduardo: 2 articles (03/2015 - 11/2009)|
|3.||Novoa-Carballal, Ramon: 2 articles (03/2015 - 11/2009)|
|4.||Gursoy-Ozdemir, Yasemin: 2 articles (03/2015 - 11/2009)|
|5.||Andrieux, Karine: 2 articles (03/2015 - 11/2009)|
|6.||Yemisci, Muge: 2 articles (03/2015 - 11/2009)|
|7.||Riguera, Ricardo: 2 articles (03/2015 - 11/2009)|
|8.||Capan, Yilmaz: 2 articles (03/2015 - 11/2009)|
|9.||Caban, Secil: 2 articles (03/2015 - 11/2009)|
|10.||Yan, Hua: 2 articles (01/2015 - 12/2010)|
|1.||Optic Nerve Injuries
01/01/2015 - "Because the second messenger caspase-3 plays a major role in apoptosis, we now evaluated the efficacy of the specific caspase-3 inhibitor, Z-DEVD-FMK, in a rabbit model of fluid percussion injury (FPI) which mimics traumatic optic nerve injury in humans to enhance cell survival and improve vision. "
12/01/2010 - "z-DEVD-fmk is effective in treating rabbit optic nerve injury by inhibiting the expression of caspase-3 in the retina. "
12/01/2010 - "[Experimental study on treatment of rabbits optic nerve injury with Caspase-3 inhibitor z-DEVD-fmk]."
01/01/2015 - "Caspase-3 inhibitor Z-DEVD-FMK enhances retinal ganglion cell survival and vision restoration after rabbit traumatic optic nerve injury."
12/01/2010 - "To observe the effects of caspase-3 inhibitor z-DEVD-fmk on optic nerve injury of rabbits. "
|2.||Brain Injuries (Brain Injury)
10/01/2004 - "In studies designed to evaluate the therapeutic window for treatment of traumatic brain injury, the caspase 3 inhibitor z-DEVD-fmk improved neurologic function and reduced lesion volumes when administered at 1 but not at 4, 8, or 24 hours after injury. "
10/01/2004 - "Caspase inhibitor z-DEVD-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury."
10/01/2004 - "In a cell free assay, z-DEVD-fmk reduced hydrolysis of casein by purified calpain I. Finally, z-DEVD-fmk reduced expression of the 145 kD calpain-mediated alpha-spectrin cleavage fragment after traumatic brain injury in vivo. "
|4.||Brain Ischemia (Cerebral Ischemia)
01/01/2012 - "N-Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethyl ketone (Z-DEVD-FMK)-loaded nanoparticles rapidly release their contents within brain parenchyma, inhibit ischemia-induced caspase-3 activity, and thereby provide neuroprotection."
09/01/2003 - "Group D consisted of animals subjected to experimental ischemia and to a dose of the caspase inhibitors z-VAD.FMK and z-DEVD.FMK injected intracerebroventricularly through the right hemisphere before the surgical procedure. "
07/01/1998 - "Furthermore, ventricular infusion of Z-DEVD-FMK, a caspase-3 inhibitor, decreased caspase-3 activity in the hippocampus and significantly reduced cell death and DNA fragmentation in the CA1 sector up to 7 d after ischemia. "
03/01/1998 - "Hence, 30 minutes of reversible ischemia augments apoptotic cell death, which can be attenuated by delayed z-VAD.FMK and z-DEVD.FMK administration with preservation of neurologic function. "
11/04/2009 - "Pre- or post-treatment (2 h) with intravenously injected Z-DEVD-FMK-loaded nanospheres dose dependently decreased the infarct volume, neurological deficit, and ischemia-induced caspase-3 activity in mice subjected to 2 h of MCA occlusion and 24 h of reperfusion, suggesting that they released an amount of peptide sufficient to inhibit caspase activity. "
|1.||Caspase 3 (Caspase-3)
|2.||benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone
|4.||benzoylcarbonyl- valyl- aspartyl- valyl- alanyl- aspartyl- fluoromethyl ketone
|5.||benzyloxycarbonyl- leucyl- glutamyl- histidyl- aspartic acid fluoromethyl ketone
|10.||Caspase 8 (Caspase-8)