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hydrodolasetron
active metabolite of dolasetron
Also Known As:
1-H-indole-3-carboxylic acid, trans-octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester; MDL 74156; MDL-74156; 1H-Indole-3-carboxylic acid, octahydro-3-hydroxy-2,6-methano-2H-quinolizin-8-yl ester
Networked:
2
relevant articles (
0
outcomes,
1
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
hydrodolasetron: 2
Quinolizines: 1
hydrodolasetron: 2
Related Diseases
1.
Neoplasms (Cancer)
05/01/1999 - "
The intent of this study was to obtain preliminary data on the pharmacokinetics of the active metabolite, hydrodolasetron, in cancer patients.
"
05/01/1999 - "
The pharmacokinetics of hydrodolasetron were studied after administration of a single intravenous infusion of 0.6 mg/kg (group I) or 1.8 mg/kg (group II) in 21 cancer patients participating in a randomized, double-blind, parallel-group, multicenter trial of the drug in patients receiving their first course of high-dose (>/=75 mg/m ( 2 ) ) cisplatin-containing chemotherapy.
"
2.
Neuroblastoma
08/14/1992 - "
In radioligand binding experiments, MDL 73147EF and MDL 74156 inhibited the binding of [3H]GR65630 to 5-hydroxy-tryptamine3 (5-HT3) binding sites on membranes prepared from NG108-15 neuroblastoma x glioma cells.
"
08/14/1992 - "
Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells.
"
3.
Glioma (Gliomas)
08/14/1992 - "
In radioligand binding experiments, MDL 73147EF and MDL 74156 inhibited the binding of [3H]GR65630 to 5-hydroxy-tryptamine3 (5-HT3) binding sites on membranes prepared from NG108-15 neuroblastoma x glioma cells.
"
08/14/1992 - "
Characterization of the novel 5-HT3 antagonists MDL 73147EF (dolasetron mesilate) and MDL 74156 in NG108-15 neuroblastoma x glioma cells.
"
Related Drugs and Biologics
1.
Serotonin 5-HT3 Receptor Antagonists
2.
Mesylates (Mesylate)
3.
Cisplatin (Platino)
4.
dolasetron (Anzemet)
5.
GR 65630
Related Therapies and Procedures
1.
Intravenous Infusions
2.
Drug Therapy (Chemotherapy)