UGT1A6 UDP-glucuronosyltransferase

RefSeq NM_205862

Also Known As:

UDP-glucuronosyltransferase, UGT1A6; UDP glycosyltransferase 1 family, polypeptide A6, human; UGT1A6 protein, human; human UGT1A6; uridine diphosphate glucuronosyltransferase 1A6; uridine diphosphate glucuronosyltransferase 1A6, human

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Glycosyltransferases: 784
      - Hexosyltransferases
        Glucuronosyltransferase: 625
        UGT1A6 UDP-glucuronosyltransferase: 5

Experts

1.	Casey, Graham: 1 article (05/2009)
2.	Cheng, Iona: 1 article (05/2009)
3.	Li, Li: 1 article (05/2009)
4.	Merkulova, Alona: 1 article (05/2009)
5.	Plummer, Sarah-J: 1 article (05/2009)
6.	Thompson, Cheryl-L: 1 article (05/2009)
7.	Tucker, Thomas-C: 1 article (05/2009)
8.	Mizutani, Takaharu: 1 article (12/2007)
9.	Mori, Hitomi: 1 article (12/2007)
10.	Shinoda, Masakazu: 1 article (12/2007)

Related Diseases

1.	Carcinoma (Carcinomatosis) 01/01/1998 - "3. Transient transfection studies, using human UGT1A6/CAT fusion constructs and colon carcinoma Caco-2 cells, revealed that PAH induction of human UGT1A6 is mediated by the Ah receptor. "
2.	Autoimmune Hepatitis 12/01/2007 - "The N-terminal of human UGT1A6 is on the outside, as evidenced by ELISA with autoantibody in autoimmune hepatitis sera."
3.	Hepatocellular Carcinoma (Hepatoma) 09/01/2003 - "Contribution of the Ah receptor to the phenolic antioxidant-mediated expression of human and rat UDP-glucuronosyltransferase UGT1A6 in Caco-2 and rat hepatoma 5L cells."
4.	Gilbert Disease 04/01/2007 - "On the basis of a case of hyperserotoninaemia in the absence of a detectable carcinoid tumour in a patient with Gilbert's syndrome, who presented with a history of night sweats, flushing, abdominal discomfort and intermittent diarrhoea, we propose that in a subgroup of Gilbert's syndrome patients, homozygocity for dual uridine diphosphate-glucuronosyltransferase 1A1 and uridine diphosphate-glucuronosyltransferase 1A6 polymorphisms may lead to combined hyperbilirubinaemia and hyperserotoninaemia. "
5.	Flushing 04/01/2007 - "On the basis of a case of hyperserotoninaemia in the absence of a detectable carcinoid tumour in a patient with Gilbert's syndrome, who presented with a history of night sweats, flushing, abdominal discomfort and intermittent diarrhoea, we propose that in a subgroup of Gilbert's syndrome patients, homozygocity for dual uridine diphosphate-glucuronosyltransferase 1A1 and uridine diphosphate-glucuronosyltransferase 1A6 polymorphisms may lead to combined hyperbilirubinaemia and hyperserotoninaemia. "

Related Drugs and Biologics

1.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
2.	Cyclooxygenase 2 (Cyclooxygenase-2)
3.	Uridine Diphosphate (UDP)
4.	Glucuronosyltransferase (UDP Glucuronosyltransferase)
5.	Autoantibodies
6.	Antioxidants
7.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)