EAA-090

a potent N-methyl-D-aspartate antagonist; structure in first source

Also Known As:

(2-(8,9-Dioxo-2,6-diazabicyclo(5.2.0)non-1(7)-en-2-yl)ethyl)phosphonic acid; 2-(dioxo-2,6-diazabicyclo(5.2.0)non-ethyl) phosphonic acid; EAA 090; perzinfotel

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - EAA-090: 3
- Aza Compounds: 3
  - Azabicyclo Compounds
    - EAA-090: 3
Heterocyclic Compounds: 198
- Bridged-Ring Heterocyclic Compounds
  - Heterocyclic Bridged Bicyclo Compounds
    - Azabicyclo Compounds
      - EAA-090: 3

Experts

1.	Brandt, Michael R: 2 articles (02/2009 - 06/2005)
2.	Cummons, Terri A: 2 articles (02/2009 - 06/2005)
3.	Al-Nadaf, Sami: 1 article (06/2011)
4.	Budsberg, Steven C: 1 article (06/2011)
5.	Cathcart, Curtis J: 1 article (06/2011)
6.	Clark, James D: 1 article (06/2011)
7.	Eppler, C Mark: 1 article (06/2011)
8.	Reynolds, Lisa R: 1 article (06/2011)
9.	Torres, Bryan T: 1 article (06/2011)
10.	Zwijnenberg, Raphael J: 1 article (06/2011)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 02/12/2009 - "Previous studies with perzinfotel (1), a potent, selective, competitive NMDA receptor antagonist, showed it to be efficacious in inflammatory and neuropathic pain models. "
2.	Hypersensitivity (Allergy) 06/01/2005 - "The current study evaluated whether perzinfotel would have antinociceptive effects or block thermal hypersensitivity associated with the administration of chemical irritants in rats. " 06/01/2005 - "In contrast to other negative modulators of the NMDA receptor studied, which typically decreased operant rates of responding at doses that lacked antinociceptive effects, perzinfotel did not modify response rates at doses that blocked irritant-induced thermal hypersensitivity. " 06/01/2005 - "Perzinfotel lacked antinociceptive effects but dose- and time-dependently blocked prostaglandin E(2) (PGE(2))- and capsaicin-induced thermal hypersensitivity in a warm-water tail-withdrawal assay in rats. " 06/01/2005 - "Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity."
3.	Synovitis 06/01/2011 - "Effect of perzinfotel and a proprietary phospholipase A(2) inhibitor on kinetic gait and subjective lameness scores in dogs with sodium urate-induced synovitis." 06/01/2011 - "To investigate the ability of perzinfotel (an N-methyl-d-aspartate receptor antagonist) and a proprietary phospholipase A(2) (PLA(2)) inhibitor to attenuate lameness in dogs with sodium urate (SU)-induced synovitis. "

Related Drugs and Biologics

1.	N-Methyl-D-Aspartate Receptors (NMDA Receptors)
2.	EAA-090
3.	Uric Acid (Urate)
4.	Prostaglandins
5.	Phospholipases (Phospholipase)
6.	Irritants (Vesicants)
7.	Capsaicin (Zostrix)
8.	phosphonic acid