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4-nerolidylcatechol

scavenges peroxyl radicals; inhibits Fe(II)-dependent DNA damage; isolated from Pothomorphe; structure in first source

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Catechols: 121
        4-nerolidylcatechol: 7

Experts

1.	Alves-Fernandes, Débora Kristina: 2 articles (07/2020 - 01/2019)
2.	Barros, Silvia Berlanga de Moraes: 2 articles (07/2020 - 01/2019)
3.	Faião-Flores, Fernanda: 2 articles (07/2020 - 01/2019)
4.	Maria-Engler, Silvya Stuchi: 2 articles (07/2020 - 01/2019)
5.	Oliveira, Érica Aparecida de: 2 articles (07/2020 - 01/2019)
6.	Felipe-Silva, Aloisio Souza: 1 article (07/2020)
7.	Fock, Ricardo Ambrósio: 1 article (07/2020)
8.	Hastreiter, Araceli Aparecida: 1 article (07/2020)
9.	Turato, Walter: 1 article (07/2020)
10.	Alicea-Rebecca, Gretchen: 1 article (01/2019)

Related Diseases

1.	Melanoma (Melanoma, Malignant) 07/01/2020 - "In vivo antitumoral effect of 4-nerolidylcatechol (4-NC) in NRAS-mutant human melanoma." 02/01/2009 - "Apoptosis induction by 4-nerolidylcatechol in melanoma cell lines." 01/01/2019 - "Early results from our group indicated that 4-nerolidylcatechol (4-NC), a catechol compound extracted from Pothomorphe umbellata, induces DNA damage, ROS production, increased p53 expression culminating in apoptosis in melanoma but with no data regarding the 4-NC effects in cells resistant to BRAFi or MEKi. " 09/01/2013 - "4-Nerolidylcatechol (4-NC) is found in Pothomorphe umbellata root extracts and is reported to have a topical protective effect against UVB radiation-induced skin damage, toxicity in melanoma cell lines, and antimalarial activity. " 05/01/2012 - "4-Nerolidylcatechol (4-NC) is a potent antioxidant whose cytotoxic potential has already been demonstrated in melanoma tumor cell lines. "
2.	Schistosomiasis (Bilharziasis) 09/15/2023 - "umbellata root extracts and the isolated compound 4-nerolidylcatechol (4-NC) against Schistosoma mansoni ex vivo and in murine models of schistosomiasis. "
3.	Prostatic Neoplasms (Prostate Cancer) 01/01/2023 - "4-Nerolidylcatechol (4-NC) and Docetaxel Synergize in Controlling Androgen- independent Prostate Cancer Cells."

Related Drugs and Biologics

1.	Proteasome Endopeptidase Complex (Proteasome)
2.	Antioxidants
3.	Antimalarials (Antimalarial Agents)
4.	Androgens
5.	Docetaxel (Taxotere)
6.	catechol (pyrocatechol)