RNase Z

isolated from potato

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

1.	Cardiomyopathies (Cardiomyopathy) 01/01/2023 - "In this study, we used CRISPR-TRiM technology to create Drosophila models that carry cardiomyopathy-linked alleles of RNase Z only in the cardiomyocytes. "
2.	Prostatic Neoplasms (Prostate Cancer) 10/01/2019 - "One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, suggesting a functional link between tumorigenesis and mitochondrial RNA metabolism." 08/01/2023 - "Stentenbach and colleagues have unveiled a functional role of a human germline mutation found in the ribonuclease (RNase) Z enzyme, ELAC2, in prostate cancer. "
3.	Carcinogenesis 10/01/2019 - "One rare missense variant associated with the occurrence of prostate cancer (p.Arg781His) impairs the mitochondrial RNase Z activity of ELAC2, suggesting a functional link between tumorigenesis and mitochondrial RNA metabolism."
4.	Muscle Hypotonia (Hypotonia) 01/01/2023 - "Patients carrying RNase Z variants with reduced enzymatic activity display a plethora of symptoms including muscular hypotonia, microcephaly and severe heart hypertrophy; still, they die primarily due to acute heart decompensation. "
5.	Microcephaly 01/01/2023 - "Patients carrying RNase Z variants with reduced enzymatic activity display a plethora of symptoms including muscular hypotonia, microcephaly and severe heart hypertrophy; still, they die primarily due to acute heart decompensation. "

1.	Zinc
2.	Staphylococcal Protein A (Protein A)
3.	Ribonucleases (Ribonuclease)
4.	Phosphoric Diester Hydrolases (Phosphodiesterases)
5.	Ligases (Synthetase)
6.	Enzymes
7.	Carbamyl Phosphate (Carbamoyl Phosphate)
8.	Mitochondrial RNA