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khasianine

structure in first source

Also Known As:

L-rhamnopyranosyl-14-D-glucopyranose solasodine

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chen, Xun: 1 article (06/2022)
2.	Deng, Yu: 1 article (06/2022)
3.	Su, Zhou: 1 article (06/2022)
4.	Yang, Yixi: 1 article (06/2022)
5.	Zhang, Yujin: 1 article (06/2022)
6.	Zhao, Qi: 1 article (06/2022)
7.	Akter, Raushanara: 1 article (01/2015)
8.	Grice, I Darren: 1 article (01/2015)
9.	Tiralongo, Evelin: 1 article (01/2015)
10.	Tiralongo, Joe: 1 article (01/2015)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 06/28/2022 - "Our results suggested that Khasianine is a potent anti-inflammatory compound with the bioactivity of NF-κB inhibition and is a promising candidate for psoriasis topical therapy." 06/28/2022 - "This study tried to explore the bioactivity of Khasianine and showed that Khasianine possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation. " 06/28/2022 - "Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes."
2.	Inflammation (Inflammations) 06/28/2022 - "This study tried to explore the bioactivity of Khasianine and showed that Khasianine possessed highly anti-inflammatory bioactivity which rapidly alleviated psoriasis-like mice skin inflammation. " 06/28/2022 - "Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-α/NF-κB axis mediated transactivation of IL-17A and IL-33 in keratinocytes."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 05/12/2023 - "This study explored the antiproliferative activity of khasianine against pancreatic cancer cell lines of human (Suit2-007) and rat (ASML) origin. " 05/12/2023 - "The antiproliferative effect of khasianine in pancreatic cancer cells and the downregulation of rhamnose-sensitive proteins underscore the potential of khasianine in treating pancreatic cancer." 05/12/2023 - "Khasianine Affects the Expression of Sugar-Sensitive Proteins in Pancreatic Cancer Cells, Which Are Altered in Data from the Rat Model and Patients."
4.	Neoplasms (Cancer) 06/28/2022 - "In vitro, tumor necrosis factor α (TNF-α) treated HaCaT cells with or without Khasianine, were used to analyze the expression and cellular location of NF-κB p65, the expression of IL-17A and IL-33, and the binding intensity of NF-κB p65 on the promoter of IL-17A and IL-33 to understand the molecular mechanism of Khasianine mediated anti-inflammatory effect. " 01/01/2015 - "Cytotoxic activity of 1 and seven SGA analogues and steroidal alkaloids (SAs), (β-solamarine, α-solanine, β-solamargine, α-solasonine, khasianine, solasodine, tomatidine HCl) were evaluated for their cytotoxicity against two healthy (NIH3T3 and VERO) and four human cancer (AGS, HT-29, MCF-7 and MDA-MB-231) cell lines using the MTT assay. "
5.	Necrosis 06/28/2022 - "In vitro, tumor necrosis factor α (TNF-α) treated HaCaT cells with or without Khasianine, were used to analyze the expression and cellular location of NF-κB p65, the expression of IL-17A and IL-33, and the binding intensity of NF-κB p65 on the promoter of IL-17A and IL-33 to understand the molecular mechanism of Khasianine mediated anti-inflammatory effect. "

Related Drugs and Biologics

1.	Interleukin-17 (Interleukin 17)
2.	Interleukin-33
3.	beta-solamarine
4.	Solanine
5.	Rhamnose
6.	Proteins (Proteins, Gene)
7.	Alkaloids
8.	Sugars
9.	alpha-solamargine
10.	solasodine

Related Therapies and Procedures

1.	Therapeutics