32-O-(1-hydroxyethylindol-5-yl)ascomycin

a tacrolimus-related immunosuppressant with reduced toxicity; structure in first source

Also Known As:

L 732531; L-732,531; indolyl-ASC; indolyl-ascomycin

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

1.	Autoimmune Diseases (Autoimmune Disease) 01/15/1998 - "Indolyl-ASC may define those properties needed to increase the therapeutic efficacy of a macrolactam immunoregulant for treating both human autoimmune disease and organ transplant rejection."
2.	Hypothermia 01/15/1998 - "Further evaluation of indolyl-ASC revealed that it is threefold less potent than tacrolimus in inducing hypothermia, a response that may reflect neurotoxicity, and in causing gastrointestinal transit alterations in mice. "

1.	Tacrolimus (Prograf)