AM 281

radioligand for cannabinoid CB1 receptors; structure in first source

Also Known As:

AM-281; AM281 cpd; N-(morpholin-4-yl)-5-(4-iodophenyl)-1-(2,4-dichlorphenyl)-4-methyl-1H-pyrazole-3-carboxamide

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Brain Diseases (Brain Disorder) 11/01/2005 - "Although further studies are necessary to determine whether endogenous cannabinoids cause septic encephalopathy in rats directly or via their effects on systemic hemodynamics, the beneficial effects of AM 281 on these rats might have significant therapeutic implications in cases of septic encephalopathy."
2.	Sepsis (Septicemia) 11/01/2005 - "It was found that administration of AM 281 could prevent the hemodynamic changes induced by sepsis. "
3.	Septic Shock (Toxic Shock Syndrome) 11/01/2005 - "Administration of AM 281 prevented the hemodynamic changes and development of neurologic dysfunction occurring in association with septic shock, and could decrease the mortality rate in experimentally induced septic shock in rats. "
4.	Neurologic Manifestations (Neurological Manifestations) 11/01/2005 - "Administration of AM 281 prevented the hemodynamic changes and development of neurologic dysfunction occurring in association with septic shock, and could decrease the mortality rate in experimentally induced septic shock in rats. " 11/01/2005 - "Cannabinoid antagonist AM 281 reduces mortality rate and neurologic dysfunction after cecal ligation and puncture in rats."

1.	Cannabinoids
2.	Cannabinoid Receptor Antagonists