|1.||Jäättelä, Marja: 6 articles (09/2013 - 10/2005)|
|2.||Nylandsted, Jesper: 4 articles (09/2013 - 03/2007)|
|3.||Groth-Pedersen, Line: 4 articles (09/2013 - 03/2007)|
|4.||Ostenfeld, Marie Stampe: 3 articles (05/2008 - 10/2005)|
|5.||Høyer-Hansen, Maria: 3 articles (05/2008 - 10/2005)|
|6.||Petersen, Nikolaj H T: 2 articles (09/2013 - 01/2012)|
|7.||Fehrenbacher, Nicole: 2 articles (05/2008 - 10/2005)|
|8.||Farkas, Thomas: 2 articles (05/2008 - 10/2005)|
|9.||Ostenfeld, Marie S: 1 article (09/2013)|
|10.||Bilgin, Mesut: 1 article (09/2013)|
09/09/2013 - "Like siramesine, several clinically relevant ASM inhibitors trigger cancer-specific lysosomal cell death, reduce tumor growth in vivo, and revert multidrug resistance. "
05/01/2008 - "Threrefore, the combination of siramesine with inhibitors of autophagosome formation appears as a promising approach for future cancer therapy."
05/01/2008 - "Importantly, pharmacological and RNA interference-based inhibition of autophagosome formation further sensitizes cancer cells to siramesine-induced cytotoxicity. "
10/01/2005 - "These results present siramesine as a promising new drug for the treatment of tumors resistant to traditional therapies."
01/01/2013 - "A sigma-2 receptor agonist siramesine has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. "
|2.||Breast Neoplasms (Breast Cancer)
10/01/2005 - "administration of well-tolerated doses of siramesine had a significant antitumorigenic effect in orthotopic breast cancer and s.c. "
03/01/2007 - "Consistent with its substantial effects on the lysosomes, vincristine greatly sensitized cultured cancer cells as well as orthotopic breast cancer xenografts in mice to the cytotoxicity induced by siramesine, a sigma-2 receptor ligand that kills cancer cells by destabilizing their lysosomes. "
12/01/1997 - "Furthermore, Lu 28-179 reversed shock-induced suppression of drinking in the rat (MED = 18,000 nmol/kg = 10 mg/kg). "
12/01/1997 - "Lu 28-179 was over 100 times more potent than diazepam in the rat and mouse black and white test box and the rat social interaction test, whereas the potency of Lu 28-179 was comparable to that of lorazepam in reversal of shock-induced suppression of drinking. "
|5.||Dehydration (Water Stress)
|2.||Small Interfering RNA (siRNA)
|3.||Reactive Oxygen Species (Oxygen Radicals)
|6.||Peptide Hydrolases (Proteases)
|1.||Heterologous Transplantation (Xenotransplantation)