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Ro 25-6981

blocks NMDA receptors containg NR2B subunit; structure in first source
Also Known As:
Ro-25-6981; alpha-(4-hydroxyphenyl)-beta-methyl--4-(phenylmethyl)-1-piperidine propanol
Networked: 17 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Tsironis, Christos: 2 articles (05/2012 - 04/2006)
2. Konitsiotis, Spiridon: 2 articles (05/2012 - 04/2006)
3. Herrera, Jairo: 2 articles (05/2012 - 01/2011)
4. Lin, Ling: 1 article (06/2014)
5. Chen, Ai-qin: 1 article (06/2014)
6. Chen, Yu: 1 article (06/2014)
7. Bao, Cheng-jia: 1 article (06/2014)
8. Luo, Xiao-qing: 1 article (06/2014)
9. Tang, Ying: 1 article (06/2014)
10. Guo, Li-xia: 1 article (06/2014)

Related Diseases

1. Dyskinesias (Dyskinesia)
2. Movement Disorders (Movement Disorder)
3. Pain (Aches)
4. Hyperalgesia
11/01/2013 - "Antinociception and prevention of hyperalgesia by intrathecal administration of Ro 25-6981, a highly selective antagonist of the 2B subunit of N-methyl-D-aspartate receptor."
05/01/1999 - "(+/-)-Ro 25-6981 also showed a significant separation (ID50 allodynia 3.8 mg/kg, i.p.), however, some disruption of rotarod performance was observed at 100 mg/kg. The anticonvulsant lamotrigine (3-500 mg/kg p.o.) also showed a good dose window. "
11/01/2013 - "In this study, we used a rat model of incisional pain to investigate effects of postoperative analgesia and changes of postoperative hyperalgesia induced by remifentanil through the pretreatment of intrathecal administration with Ro 25-6981. "
11/01/2013 - "Intrathecal injection of Ro 25-6981 had significant analgesic effects on incision pain in rats and effectively attenuated postoperative hyperalgesia induced by remifentanil."
07/01/2007 - "with CGS 19755 (selective antagonist of the NMDAR), CGP 78608 [[(1S)-1-[[(7-bromo-1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl]amino]ethyl]phosphonic acid] (selective antagonist at the glycine-binding site of the NMDAR), ifenprodil and Ro 25-6981 (selective antagonists of the NR2B subunit of the NMDAR), bisindolylmaleimide I and Go-7874 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] (inhibitors of protein kinase C), or PKI-(14-22)-amide [Myr-N-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH(2)] (inhibitor of protein kinase A) dose-dependently inhibited the hyperalgesia induced by i.t. "
5. Shock

Related Drugs and Biologics

1. ifenprodil
2. Amantadine (Aman)
3. 2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)
4. remifentanil (Ultiva)
5. N-Methylaspartate (NMDA)
6. Levodopa (L Dopa)
7. Formaldehyde (Formol)
8. AMPA Receptors (AMPA Receptor)
9. Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
10. 2-Amino-5-phosphonovalerate (2 Amino 5 phosphonovalerate)

Related Therapies and Procedures

1. Analgesia
2. Spinal Injections