pergularinine

RN refers to (13aS-cis)-isomer; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 06/19/1998 - "Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine."
2.	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/19/1998 - "Thymidylate synthase activity in leukocytes from patients with chronic myelocytic leukemia and acute lymphocytic leukemia and its inhibition by phenanthroindolizidine alkaloids pergularinine and tylophorinidine."
3.	Neoplasms (Cancer) 10/24/1997 - "Biological activity of the phenanthroindolizidine alkaloids pergularinine (PGL) and tylophorinidine (TPD) isolated from the Indian medicinal herb Pergularia pallida has been evaluated and assessed for the first time employing thymidylate synthase (TS) (5,10-CH2H4 PteGlu: dUMP-C-methyltransferase, EC 2.1.1.45), a key target enzyme in cancer chemotherapy. "

1.	Drug Therapy (Chemotherapy)