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mutein 5

differs from the native TNF-alpha in its N-terminal sequence

Also Known As:

mutein V

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycoconjugates: 1353
  - Glycoproteins: 24834
    - Tumor Necrosis Factor-alpha: 62515
      - mutein 5: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - Cytokines: 164289
      - Monokines: 214
        Tumor Necrosis Factor-alpha: 62515
        mutein 5: 2
      - Tumor Necrosis Factors: 152
        Tumor Necrosis Factor-alpha: 62515
        mutein 5: 2
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - Cytokines: 164289
    - Monokines: 214
      - Tumor Necrosis Factor-alpha: 62515
        mutein 5: 2
    - Tumor Necrosis Factors: 152
      - Tumor Necrosis Factor-alpha: 62515
        mutein 5: 2

Experts

1.	Nowak, H F: 1 article (02/2000)
2.	Terlikowski, S: 1 article (02/2000)

Related Diseases

1.	Neoplasms (Cancer) 02/01/2000 - "three times a week with 10 micrograms/mice of rhTNF-alpha, mutein V or mutein VI for two weeks, starting on the 4th day after tumor inoculation. "
2.	Carcinoma (Carcinomatosis) 03/01/1993 - "We observed binding to the p75 TNF receptor on Jijoye Burkitt lymphoma cells with native TNF-alpha and mutein III alone, whereas the p55 TNF receptor on the human epithelioid carcinoma cell line HeLa bound TNF-alpha, mutein III and mutein V. Muteins IV and VI failed to recognize either TNF receptor. "
3.	Burkitt Lymphoma (Burkitt's Lymphoma) 03/01/1993 - "We observed binding to the p75 TNF receptor on Jijoye Burkitt lymphoma cells with native TNF-alpha and mutein III alone, whereas the p55 TNF receptor on the human epithelioid carcinoma cell line HeLa bound TNF-alpha, mutein III and mutein V. Muteins IV and VI failed to recognize either TNF receptor. "
4.	Ascites 02/01/2000 - "The number of EAT cells in ascites decreased after rhTNF-alpha and mutein V administration (p < 0.001). "

Related Drugs and Biologics

1.	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	mutein 3
4.	mutein 6