sclareolide

has antineoplastic activity; synthesized by oxidation of sclareol; a minor constituent of Arnica angustifolia and Sideritis nutans; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Sheng: 1 article (04/2017)
2.	Dong, Mao-Sheng: 1 article (04/2017)
3.	Wang, Ye: 1 article (04/2017)
4.	Zhang, Jian-Hua: 1 article (04/2017)
5.	Zhang, Wen-Long: 1 article (04/2017)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 04/01/2017 - "Sclareolide enhances gemcitabine‑induced cell death through mediating the NICD and Gli1 pathways in gemcitabine‑resistant human pancreatic cancer." 04/01/2017 - "Sclareolide may be a novel agent in combination with gemcitabine for the treatment of gemcitabine‑resistant pancreatic cancer, which resensitizes GR‑HPCCs to gemcitabine through mediating NICD and Gli1."
2.	Neoplasms (Cancer) 04/01/2017 - "Finally, sclareolide resensitized GR‑HPCCs to gemcitabine through inducing apoptosis; in vivo, the co‑administraion of sclareolide and gemcitabine effectively suppressed tumor growth. "

Related Drugs and Biologics

1.	Gemcitabine