|1.||Casas, Josefina: 3 articles (10/2014 - 09/2009)|
|2.||Ghidoni, Riccardo: 2 articles (12/2012 - 09/2009)|
|3.||Signorelli, Paola: 2 articles (12/2012 - 09/2009)|
|4.||Gagliostro, Vincenzo: 2 articles (12/2012 - 09/2009)|
|5.||Asumendi, Aintzane: 2 articles (04/2012 - 01/2011)|
|6.||Hannun, Yusuf A: 2 articles (04/2012 - 01/2011)|
|7.||Boyano, María Dolores: 2 articles (04/2012 - 01/2011)|
|8.||Apraiz, Aintzane: 2 articles (04/2012 - 01/2011)|
|9.||Illuzzi, Giuditta: 2 articles (07/2010 - 06/2010)|
|10.||Aureli, Massimo: 2 articles (07/2010 - 06/2010)|
02/01/2012 - "These findings provide a molecular basis of γTE-stimulated cancer cell death and support the notion that elevation of intracellular dihydroceramide and dihydrosphingosine is likely a novel anticancer mechanism."
01/01/2011 - "Ceramide and, more recently, other sphingolipid species (e.g., dihydroceramide and dihydrosphingosine) have been implicated in 4-HPR-mediated tumor cell death. "
09/01/2008 - "N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing."
05/20/2003 - "To investigate the characteristics of dihydroceramide synthase, we prepared microsomes from Sarcoma 180 tumor masses and healthy mouse liver cells, and compared their catalytic activities on dihydroceramide formation. "
05/20/2003 - "To clarify which pathway tumor cells use to form ceramide and how its formation is regulated, we determined the levels of dihydroceramide and ceramide in mice inoculated with Sarcoma 180, B16 melanoma or Lewis lung carcinoma cells. "
11/01/2014 - "Hypoxia has been previously shown to inhibit the dihydroceramide (DHC) desaturase, leading to the accumulation of DHC. "
06/01/2013 - "We have also shown that its precursor, dihydroceramide, accumulates with hypoxia. "
11/04/2011 - "Dihydroceramide-based response to hypoxia."
08/01/1998 - "Exposure of LLC-PK1 cells to synthetic ceramide, C2- and C6-ceramide, but not C2-dihydroceramide, the structural analog of C2-ceramide, resulted in DNA strand breaks, DNA fragmentation and cell death in a dose- and time-dependent manner similar to the effect of chemical hypoxia. "
12/01/2012 - "We previously demonstrated that dihydroceramide accumulation, in response to treatment with the dihydroceramide desaturase inhibitor XM462, induced autophagy with no sign of cell death in the gastric carcinoma HCG27 cell line. "
06/11/2010 - "A2780 human ovarian carcinoma cells respond to treatment with the synthetic retinoid N-(4-hydroxyphenyl)retinamide (HPR) with the production of dihydroceramide and with a concomitant reduction of cell proliferation and induction of apoptosis. "
07/01/2010 - "The dihydroceramide, ceramide, sphingomyelin, lactosylceramide, and ganglioside species of A2780 human ovarian carcinoma cells treated with the synthetic retinoids N-(4-hydroxyphenyl)retinamide (fenretinide, 4-HPR) and 4-oxo-N-(4-hydroxyphenyl)retinamide (4-oxo-4-HPR) in culture were characterized by ESI-MS. We characterized 32 species of ceramide and dihydroceramide, 15 of sphingomyelin, 12 of lactosylceramide, 9 of ganglioside GM2, and 6 of ganglioside GM3 differing for the long-chain base and fatty acid structures. "
|4.||Lewis Lung Carcinoma
|5.||Stomach Neoplasms (Stomach Cancer)
|4.||Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)
|6.||Myristic Acid (Tetradecanoic Acid)
|7.||Reactive Oxygen Species (Oxygen Radicals)
|9.||Sphingomyelin Phosphodiesterase (Sphingomyelinase)