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palmitoyl trifluoromethyl ketone

phospholipase A2 inhibitor

Also Known As:

PACOCF3

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Ketones: 2618
  - palmitoyl trifluoromethyl ketone: 3

Experts

1.	Cunha, Fernando Queiroz: 1 article (01/2017)
2.	Cury, Yara: 1 article (01/2017)
3.	Dias, Renata Gonçalves: 1 article (01/2017)
4.	Gutiérrez, José María: 1 article (01/2017)
5.	Lomonte, Bruno: 1 article (01/2017)
6.	Picolo, Gisele: 1 article (01/2017)
7.	Sampaio, Sandra Coccuzzo: 1 article (01/2017)
8.	Sant'Anna, Morena Brazil: 1 article (01/2017)
9.	Cheon, Hyae Gyeong: 1 article (06/2011)
10.	Chung, Kun Wook: 1 article (06/2011)

Related Diseases

1.	Hyperalgesia 11/01/2010 - "Likewise, local pre-treatment with inhibitors of phospholipase A2 (PACOCF3), phospholipase C (U73122), protein kinase C (GF109203X), protein kinase A (KT-5720) or with phosphatidylinositol 3-kinase (AS605204) also consistently diminished IL-6-induced muscle hyperalgesia. " 01/01/2017 - "Hyperalgesia was inhibited by the pretreatment of the animals with cyclooxygenase inhibitor indomethacin, with type-2 cyclooxygenase inhibitor celecoxib, with AACOCF3 and PACOCF3, inhibitors of cytosolic and Ca2+-independent PLA2s, respectively, with bradykinin B2 receptor antagonist HOE 140, with antibodies against TNFα, IL-1β, IL-6 and CINC-1 and with selective ET-A (BQ-123) and ET-B (BQ-788) endothelin receptors antagonists. "
2.	Insulin Resistance 06/01/2011 - "However, inhibition of the conversion of PA to lysophosphatidylcholine (LPC) by calcium-independent phospholipase A₂ (iPLA₂) inhibitors, such as bromoenol lactone (BEL) or palmitoyl trifluoromethyl ketone (PACOCF₃), prevented insulin resistance by PA. "

Related Drugs and Biologics

1.	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)
2.	Phospholipases A2 (Phospholipase A2)
3.	Bradykinin B2 Receptor
4.	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)
5.	Endothelin Receptors (Endothelin Receptor)
6.	Cyclooxygenase Inhibitors
7.	Interleukin-6 (Interleukin 6)
8.	Protein Kinase C
9.	Phospholipases (Phospholipase)
10.	Type C Phospholipases