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seryl-tRNA(GCU)

mammalian mitochondrial tRNA that lacks the whole D arm; also found in squid; structure in first source

Also Known As:

Ser-tRNA(GCU); tRNA, Ser(GCU)

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleic Acids: 11752
  - RNA: 69704
    - Transfer RNA: 2235
      - Amino Acid-Specific Transfer RNA: 1
        Ser Transfer RNA: 104
        seryl-tRNA(GCU): 2

Related Diseases

1.	Chronic Progressive External Ophthalmoplegia (Progressive External Ophthalmoplegia) 12/01/1993 - "While the mutations in tRNA(Leu(UUR)) (np 3243) and tRNA(Gly) (np 10006), previously identified in patients with MELAS and CIPO, respectively, were found in most elderly people, the mutations in tRNA(Ser(GCU)O (np 12246) and tRNA(Asn) (np 5692), identified in patients with CIPO and CPEO, respectively, were found only in two of 15 tissue samples from different individuals. "
2.	MELAS Syndrome (Syndrome, MELAS) 12/01/1993 - "While the mutations in tRNA(Leu(UUR)) (np 3243) and tRNA(Gly) (np 10006), previously identified in patients with MELAS and CIPO, respectively, were found in most elderly people, the mutations in tRNA(Ser(GCU)O (np 12246) and tRNA(Asn) (np 5692), identified in patients with CIPO and CPEO, respectively, were found only in two of 15 tissue samples from different individuals. "
3.	Neuromuscular Diseases (Neuromuscular Disease) 04/11/1991 - "An accumulation of three different tRNA point mutations (tRNA(Leu)(UAG)), tRNA(Ser)(GCU) and tRNA(Gly) was observed in a single patient, suggesting that mitochondrial tRNA genes represent hotspots for point mutations causing neuromuscular diseases."
4.	Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction) 12/01/1993 - "While the mutations in tRNA(Leu(UUR)) (np 3243) and tRNA(Gly) (np 10006), previously identified in patients with MELAS and CIPO, respectively, were found in most elderly people, the mutations in tRNA(Ser(GCU)O (np 12246) and tRNA(Asn) (np 5692), identified in patients with CIPO and CPEO, respectively, were found only in two of 15 tissue samples from different individuals. "

Related Drugs and Biologics

1.	Leu Transfer RNA
2.	Gly Transfer RNA
3.	Asn Transfer RNA
4.	Transfer RNA (tRNA)