|1.||Ress, Anna Lena: 3 articles (05/2015 - 04/2014)|
|2.||Pichler, Martin: 3 articles (05/2015 - 04/2014)|
|3.||Gerger, Armin: 3 articles (05/2015 - 04/2014)|
|4.||Haroutunian, Vahram: 3 articles (09/2008 - 10/2005)|
|5.||Ferguson, Stephen S G: 2 articles (10/2015 - 03/2012)|
|6.||Calin, George Adrian: 2 articles (05/2015 - 09/2014)|
|7.||Schwarzenbacher, Daniela: 2 articles (05/2015 - 09/2014)|
|8.||Ivan, Cristina: 2 articles (05/2015 - 09/2014)|
|9.||Ling, Hui: 2 articles (05/2015 - 09/2014)|
|10.||Schauer, Silvia: 2 articles (05/2015 - 04/2014)|
05/14/2013 - "After adjusting for other prognostic factors, multivariate Cox regression analysis identified low expression of spinophilin as an independent prognostic factor with respect to disease-free (hazard ratio (HR)=1.8; 95% confidence interval (CI)=1.04-3.40; P=0.043) and cancer-specific survival (HR=2.0; CI=1.1-3.8; P=0.025). "
04/01/2014 - "Previous studies also indicate that a loss of spinophilin in combination with functional impairment of p53 drives tumor progression. "
09/30/2014 - "The putative tumor suppressor gene spinophilin has been involved in cancer progression in several types of cancer. "
04/01/2014 - "Overall, immunoreactivity for spinophilin was reduced in 40 tumors (47%). "
04/01/2014 - "The putative tumor suppressor protein spinophilin has been recently involved in the pathogenesis of lung, liver, and other types of cancer. "
|2.||Breast Neoplasms (Breast Cancer)
05/10/2015 - "In this study, we determined for the first time the expression pattern of spinophilin in human breast cancer molecular subtypes (n = 489) and correlated it with survival (n = 921). "
05/10/2015 - "According to our data, low levels of spinophilin are associated with aggressive behavior of breast cancer. "
05/10/2015 - "Spinophilin expression was significantly lower in basal-like breast cancer (p<0.001) and an independent poor prognostic factor in breast cancer patients (hazard ratio = 1.93, 95% confidence interval: 1.24 -3.03; p = 0.004) A reduction of spinophilin levels increased cellular growth in breast cancer cells (p<0.05), without influencing activation of apoptosis. "
05/10/2015 - "Microarray profiling was used to determine the most abundantly expressed genes in spinophilin-silenced breast cancer cells. "
05/10/2015 - "Low spinophilin expression enhances aggressive biological behavior of breast cancer."
|4.||Schizophrenia (Dementia Praecox)
01/01/2009 - "We used stereologic methods to quantify a marker of dendritic spines, spinophilin-immunoreactive (SP-IR) puncta, in deep layer 3 of BA 41 and 42 of 15 subjects with schizophrenia, each matched to a normal comparison subject. "
07/01/2005 - "Reduced spinophilin in schizophrenia."
10/01/2004 - "Decreased spinophilin but unchanged MAP2 expression provides molecular evidence for a hippocampal dendritic pathology in schizophrenia that preferentially affects the spines. "
09/15/2006 - "Transcript levels of spinophilin, a protein enriched in dendritic spines that modulates excitatory neurotransmission, were increased 22% in dorsolateral prefrontal cortex but were unchanged in anterior cingulate cortex in schizophrenia. "
10/01/2005 - "Both calcyon and spinophilin transcripts were significantly elevated in schizophrenia subjects. "
08/01/2015 - "Potential roles for Homer1 and Spinophilin in the preventive effect of electroconvulsive seizures on stress-induced CA3c dendritic retraction in the hippocampus."
02/22/2012 - "Inactivation of the neurabin gene enhanced A1R signaling and promoted the protective effect of adenosine against excitotoxic seizure and neuronal death in mice. "
08/01/2000 - "Consistent with altered glutamatergic transmission, spinophilin-deficient mice showed reduced long-term depression and exhibited resistance to kainate-induced seizures and neuronal apoptosis. "
02/22/2012 - "The enhanced anti-seizure and neuroprotective effect achieved by disruption of the A1R/neurabin/RGS4 complex is elicited by the on-site and on-demand release of endogenous adenosine, and does not require administration of A1R ligands. "
02/22/2012 - "Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine."
|1.||Proteins (Proteins, Gene)
|3.||Protein Phosphatase 1
|5.||GTP-Binding Proteins (G-Protein)
|6.||Messenger RNA (mRNA)
|7.||Dopamine Receptors (Dopamine Receptor)
|8.||Carrier Proteins (Binding Protein)
|9.||Calmodulin (Calcium-Dependent Activator Protein)